Buchler Glossary
(Asymmetric) Oxohydroxylation
Asymmetric oxohydroxylation of α-alkyl enoates with potassium permanganate catalyzed by monocationic quaternary...
(DHQ)2PHAL (CAS-No. 140924-50-1)
(DHQ)2PHAL - Dihydroquinine 1,4-phthalazinediyl diether (CAS-No. 140924-50-1) The well-known Cinchona alkaloid...
(DHQD)2PHAL (CAS-No. 140853-10-7)
(DHQD)2PHAL - Dihydroquinidine 1,4-phthalazinediyl diether (CAS-No. 140853-10-7) The well-known Cinchona alkaloid...
1,2-Addition
1,2-Addition is a type of organic chemical reaction that involves the addition of functional groups to the 1st and 2nd...
1,4-Addition (conjugate addition)
The Michael reaction is the conjugate 1,4-Addition of a resonance stabilized carbanion (michael donor) to an activated...
6`-Aminocinchonine (CAS-No. 2143936-31-4)
6´-Aminocinchonine Base (CAS-No. 2143936-31-4), a pseudoenantiomer of 6´-Aminocinchonidine, has the same...
6´-Aminocinchonidine (CAS-No. 2143936-34-7)
6´-Aminocinchonidine (CAS-No. 2143936-34-7) is a new member of the Cinchona Alkaloid family. The additional primary...
6´-Aminodihydrocinchonidine (CAS-No. 107781-90-8)
6´-Aminodihydrocinchonidine Base (CAS-No. 107781-90-8) is a cinchona alkaloid closely related to 6´-Aminocinchonidine....
6´-Aminodihydrocinchonine (CAS-No. 911708-35-5)
6´-Aminodihydrocinchonine Base (CAS-No. 911708-35-5) is a cinchona alkaloid closely related to 6´-Aminocinchonine....
Alkynylation
Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...
Allylsilylations
Allylsilylations are performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...
Aminohydroxylation
The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...
Aromatic System
Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...
Asymmetric Aldol Reaction
The aldol reaction is one of the most important and effective methodologies for the straightforward construction of...
Asymmetric Alkylation
Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Asymmetric Amination
Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is...
Asymmetric Dihydroxylation
Asymmetric Dihydroxylation of olefins is of high synthetic value because it introduces two vicinal hydroxy groups,...
Asymmetric Epoxidation
Epoxidation is treatment where an electrophilic oxidizing agent is capable of introducing a single oxygen atom to...
Asymmetric Fluorination
Fluorination is for instance a replacement of one hydrogen atom within a molecule by fluorine. The incorporation of...
Asymmetric Friedel-Crafts
Friedel-Crafts reactions in organic chemistry are referred to two main types of reactions, known as alkylation...
Asymmetric Henry Reaction (Nitroaldol Reaction)
The Henry reaction, also called Nitroaldol reaction, is a classic carbon–carbon bond formation reaction in organic...
Asymmetric Hydrogenation
Hydrogenation is a reduction reaction which results in an addition of hydrogen (often as H2). If an organic compound...
Asymmetric Mannich Reaction
In general the Mannich reaction is an aminoalkylation reaction, involving the condensation of an enolizable carbonyl...
Asymmetric Michael Addition
Michael addition / Asymmetric Michael Addition is one of the most frequently used C-C bond-forming reactions in...
Asymmetric Synthesis
Asymmetric synthesis, also called enantioselective synthesis, is a form of chemical synthesis. It is defined by IUPAC...
Atropisomers
The chirality of atropisomers is originating from restricted rotations along chemical single bonds. Atropisomers are...
Bargellini reaction
The original Bargellini reaction (1906) was a mixture of the reagents phenol, chloroform, and acetone in the presence...
Barton-Zard Reaction
The Barton-Zard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanoacetate...
Betti reaction
The three-component reaction of aldehydes, primary aromatic amines, and phenols to produce α-aminobenzylphenols is...
Bromination
Bromination is a chemical reaction in which bromine or a bromine-containing compound reacts with a substance. Finally...
Cascade reaction
A cascade reaction, also known as a domino reaction or tandem reaction, is a chemical process that comprises at least...
Chiral Compounds
Certain organic molecules are chiral - meaning that they are not superimposable on their mirror image. Chiral...
Chiral Ligands
A chiral ligand is a specially adapted ligand used for asymmetric synthesis. This ligand is an enantiopure organic...
Chiral Organocatalyst
Organocatalysts are one of the bravest attempts to mimic enzyme catalysis that Mother Nature uses. A Chiral...
Chiral Phase-Transfer Catalysts
Quaternary ammonium salts, especially derived from Cinchona Alkaloids, have become the most privileged class of Chiral...
Chiral Screening Kit
The Buchler Chiral Screening Kit contains a set of slightly different Cinchona Alkaloids in very high chemical purity....
Cinchona Alkaloids
Cinchona alkaloids are complex small molecules containing five stereogenic centers, a basic quinuclidine nitrogen, a...
Cinchonidine (CAS-No. 485-71-2)
Cinchonidine (CAS-No. 485-71-2), the pseudoenantiomer of Cinchonine Base, as a natural product is extracted from the...
Cinchonine (CAS-No. 118-10-5)
Cinchonine (CAS-No. 118-10-5), a pseudoenantiomer of Cinchonidine, is a well-known chiral compound widely used as a...
Cross-coupling
Cross-coupling reactions occur when two reagents, both with activating groups, react together with a metal catalyst to...
Cupreidine (CAS-No. 70877-75-7)
Cupreidine Base (CAS-No. 70877-75-7), as well as the pseudoenantiomer Cupreine, belong to an emerging class of...
Cupreine (CAS-No. 524-63-0)
Cupreine (CAS-No. 524-63-0) as well as its pseudoenantiomer Cupreidine are highly enantioselective bifunctional...
Cycloaddition
A cycloaddition reaction indicates the addition of two π reactants to form a cyclic adduct with formation of σ bonds...
Darzens Reaction
Darzens reaction is also known as the Darzens condensation or glycidic ester condensation. It is the chemical reaction...
Dearomatization
A dearomatization reaction is an organic reaction which involves arenes as reactants and in which the reaction...
Decarboxylation
Decarboxylation is the removal or loss of a carboxyl group from an organic compound. During the reaction carbon...
Desymmetrization
Any reaction that results in the loss of one or more symmetry elements, but especially the conversion of a prochiral...
Diastereomeric excess
The diastereomeric excess (de) reflects the degree to which a sample contains one diastereomer in greater amounts than...
Diastereomeric ratio (dr)
The diastereomeric ratio (dr) of the percent of one diastereomer in a mixture to that of the other diastereomer. For...
Diastereomers
Molecules with more than one stereocenter can be diastereomers if they are not mirror images of each other. The key...
Diels-Alder reaction
The Diels-Alder reaction is one of the most useful synthetic reactions for the construction of the cyclohexane...
Dihydrocinchonidine (CAS-No. 485-64-3)
Dihydrocinchonidine Base (CAS-No. 485-64-3) is a cinchona alkaloid closely related to Cinchonidine. Compared to...
Dihydrocinchonine (CAS-No. 485-65-4)
Dihydrocinchonine Base (CAS-No. 485-65-4) is a cinchona alkaloid closely related to Cinchonine. Compared to Cinchonine...
Dihydrocupreidine (CAS-No. 73522-75-5)
Dihydrocupreidine Base (CAS-No. 73522-75-5) is a cinchona alkaloid closely related to Cupreidine. Compared to...
Dihydrocupreine (CAS-No. 5962-19-6)
Dihydrocupreine Base (CAS-No. 5962-19-6) is a cinchona alkaloid closely related to Cupreine. Compared to Cupreine the...
Dihydroquinidine (CAS-No. 1435-55-8)
Dihydroquinidine (DHQD) (CAS-No. 1435-55-8, also called hydroquinidine) is a cinchona alkaloid closely related to...
Dihydroquinine (CAS-No. 522-66-7)
Dihydroquinine - DHQ (CAS-No. 522-66-7) is a cinchona alkaloid closely related to quinine. Compared to Quinine Base...
Domino reaction
The domino reaction is a time-resolved process in which two or more bond-forming reactions occur under similar...
Enantiomeric excess
Enantiomeric excess is a measurement of purity used for chiral substances. It reflects the degree to which a sample...
Enantiomeric ratio
The ratio of the percent of one enantiomer in a mixture to that of the other. Enantiomeric ratio of 7:3 means for...
Enantiomers
Enantiomers have identical chemical and physical properties and are indistinguishable from each other except for the...
Enantioselective (Asymmetric) Catalysis
Although nature provides us with an ample source of enantiopure chiral starting materials, the structural diversity is...
Enantioselective Aldol Reaction
The aldol reaction is one of the most important and effective methodologies for the straightforward construction of...
Enantioselective Alkylation
Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Enantioselective Amination
Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is...
Enantioselective Epoxidation
Epoxidation is treatment where an electrophilic oxidizing agent is capable of introducing a single oxygen atom to...
Enantioselective Fluorination
Fluorination is for instance a replacement of one hydrogen atom within a molecule by fluorine. The incorporation of...
Enantioselective Friedel-Crafts
Friedel-Crafts reactions in organic chemistry are referred to two main types of reactions, known as alkylation...
Enantioselective Henry Reaction (Nitroaldol Reaction)
The Henry reaction, also called Nitroaldol reaction, is a classic carbon–carbon bond formation reaction in organic...
Enantioselective Hydrogenation
Hydrogenation is a reduction reaction which results in an addition of hydrogen (often as H2). If an organic compound...
Enantioselective Mannich Reaction
In general the Mannich reaction is an aminoalkylation reaction, involving the condensation of an enolizable carbonyl...
Enantioselective Michael Addition
Michael addition / Enantioselective Michael Addition is one of the most frequently used C-C bond-forming reactions in...
Enantioselective Organocatalysis
Enantioselective organocatalysis is the best method to obtain an enantiopure compound at a high yield compared with...
Enantioselective Organocatalysts
Organocatalysts are one of the bravest attempts to mimic enzyme catalysis that Mother Nature uses. Enantioselective...
Enantioselective Synthesis
Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC...
Green Chemistry
Green chemistry is the design of chemical products and processes that reduce or eliminate the use or generation of...
Hydroarylation
Hydroarylation can be defined as the addition of an aryl group and a hydrogen atom across an unsaturated moiety...
Hydrophosphonylation
Hydrophosphonylation refers to any reaction where addition across a double bond generates a phosphonate (RP(O)(OR')2)...
Hydroxyalkylation
Hydroxyalkylation is an addition reaction that results in a hydroxyalkyl product. Hydroxyalkylation examples catalyzed...
Hydroxylation
Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. Hydroxylation...
Isomerization
Isomerization is a chemical process by which a compound is transformed into any of its isomeric forms, i.e., forms...
Knoevenagel reaction
A Knoevenagel Reaction is a condensation between an aldehyde or a ketone with an active hydrogen compound in the...
Meso compounds
Molecules that exhibit achiral properties despite having stereogenic centers are called meso compounds. Meso forms...
Morita–Baylis–Hillman reaction
Morita–Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the α-position of an activated alkene...
Nazarov cyclization
Nazarov cyclization is one of the most versatile methods for the synthesis of cyclopentenones from vinyl ketones. For...
Nobel Prize in Chemistry 2001
The Nobel Prize in Chemistry 2001 was divided, one half jointly to William S. Knowles and Ryoji Noyori "for their work...
Nobel Prize in Chemistry 2021
The Nobel Prize in Chemistry 2021 was awarded jointly to Benjamin List and David W.C. MacMillan "for the development...
Optical Rotation
Optical Rotation is the property displayed by chiral substances of rotating the plane of polarisation of polarised...
Oxaziridines
Oxaziridines are generally formed by the action of a peracid on a combination of a carbonyl compound and an amine,...
Oxosulfonylation
Oxosulfonylation is a difunctionalization where oxo and sulfonyl groups are introduced in one step to construct...
Pictet–Spengler reaction
Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or...
Pseudoenantiomers
Cinchona alkaloids exist in nature as pseudoenantiomers, which allow Cinchona alkaloid-catalyzed reactions to provide...
Quinidine (CAS-No. 56-54-2)
Quinidine Base (CAS-No. 56-54-2), a stereoisomer of the well-known Cinchona Alkaloid compound Quinine, contains the...
Quinine (CAS-No. 130-95-0)
Buchler is worldwide the leading supplier of Quinine (CAS-No. 130-95-0). It is the most famous compound of the...
Racemic Resolution
Racemic Resolution, also called optical resolution or chiral resolution, is a traditional widely-used process for the...
Rauhut-Currier reaction
The Rauhut-Currier reaction is a prominent reaction describing C-C bonds between two Michael acceptors in the presence...
Reformatsky reaction
Reformatsky reaction is an organic reaction which condenses aldehydes or ketones with α-halo esters using metallic...
Sonogashira reaction
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It...
Specific Optical Rotation
Specific Optical Rotation gives the angle of rotation of plane-polarized light by a certain compound at a certain...
Strecker reaction
The Strecker amino acid synthesis is a method for the synthesis of amino acids by the reaction of an aldehyde with...
Sulfenylation
Sulfenylation is the introduction of a sulfenyl group into a compound. Sulfenylation examples catalyzed by cinchona...
Tamura Cyclization
In the presence of a Cinchona squaramide-based catalyst, enolizable anhydrides react with alkylidene oxindoles to...
Thorpe-Ziegler reaction
Thorpe-Ziegler reaction is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the...
Wolff Rearrangement
The Wolff Rearrangement allows the generation of ketenes from α-diazoketones. During this reaction an α-diazocarbonyl...