Buchler Glossary

1,4-Addition (conjugate addition)

The Michael reaction is the conjugate 1,4-Addition of a resonance stabilized carbanion (michael donor) to an activated α,β-unsaturated compound (michael acceptor).

Please find some examples of 1,4-Additions promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.

Further Articles:


Introduction 1,2-Addition is a type of organic chemical reaction that involves the addition of functional groups to...