Buchler Glossary

Darzens Reaction

Darzens reaction is also known as the Darzens condensation or glycidic ester condensation. It is the chemical reaction of a ketone or aldehyde with an α-haloester in the presence of a base to form an α,β-epoxy ester, also called a “glycidic ester”.

Please find further examples of Darzens reaction promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.

Example from literature

Phase-transfer-catalyzed asymmetric Darzens reaction. (Arai et al.; Tetrahedron 1999, 55, 6375-6386.)

Darzens reaction

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