Buchler Glossary

Quinidine (CAS-No. 56-54-2)

Quinidine Base (CAS-No. 56-54-2), a stereoisomer of the well-known Cinchona Alkaloid compound Quinine, contains the framework of sophisticated highly efficient organocatalysts. Quinidine and its derivatives – for example Cupreidine – enables the synthesis of complex chiral compounds in high yield and with remarkable high enantioselectivitity. Please review the Chiral Screening Data Base containing hundreds of examples of asymmetric reactions using cinchona alkaloids. Compared to Quinine, the opposite configuration of target compounds can be obtained. The catalysts, are eco-friendly, highly stable and available for reasonable prices. As green catalyst these compounds are widely used in large-scale applications. Apart from its application as chiral organocatalyst Quinidine is used as a racemic resolution agent in industrial racemic resolution processes.

Pharmaceutical Application

The synthesis of the API Droxidopa is accomplished by Quinidine separating the enantiomers. The different Cinchona Alkaloids are often used in desymmetrization processes in order to obtain versatile chiral building blocks. For instance Quinidine promotes the ring opening of prochiral cyclic anhydrides in a highly efficient manner with a remarkable enantioselectivity up to 99 % ee. Desymmetrization is the key step in the synthesis of the API Telaprevir.

Apart from the asymmetric application Quinidine (CAS-No. 56-54-2) as a natural alkaloid has been used for decades to treat heart conditions such as arrhythmia. In combination with Dextromethorphan it treats the Pseudobulbar affect (PBA) – a condition that is characterized by episodes of sudden uncontrollable and inappropriate laughing or crying.

Buchler is a reliable supplier of Quinidine Salts such as Hydrocloride, Sulfate or Gluconate.

Quinidine (CAS-No. 56-54-2)

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