Buchler Glossary

1,2-addition

1,2-addition is a type of organic chemical reaction that involves the addition of functional groups to the 1st and 2nd...

Aldol Reaction

The aldol reaction unites two carbonyl compounds to form a β-hydroxy-carbonyl product, where one carbonyl compound...

Alkylation

Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...

Alkynylation

Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...

Allylsilylation

An Allylsilylation is performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...

Amination

Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is...

Aminohydroxylation

The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...

Aromatic System

Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...

Arylation

Any reaction that involves the addition of one or more aryl groups. Examples for arylations are Cross Coupling...

Bargellini Reaction

The original reaction (1906) was a mixture of the reagents phenol, chloroform, and acetone in the presence of a sodium...

Barton-Zard Reaction

The Barton–Zard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanoacetate...

Betti Reaction

The three-component reaction of aldehydes, primary aromatic amines, and phenols to produce α-aminobenzylphenols is...

Biaryls

Biaryl compounds with axial chirality are very common in synthetic chemistry, especially in catalysis. Axially chiral...

Bromination

Bromination is a chemical reaction involving the reaction of a compound and bromine. Finally bromine is being added to...

Cascade Reaction

A cascade reaction, also known as a domino reaction or tandem reaction, is a chemical process that comprises at least...

Chiral Ligand

A chiral ligand is a specially adapted ligand used for asymmetric synthesis. This ligand is an enantiopure organic...

Chiral Screening Kit

The Buchler chiral screening kit contains a set of slightly different Cinchona alkaloids in very high chemical purity....

Cinchona Alkaloids

Cinchona alkaloids are complex small molecules containing five stereogenic centers, a basic quinuclidine nitrogen, a...

Cross-Coupling

Cross-coupling reactions occur when two reagents, both with activating groups, react together with a metal catalyst to...

Cyanation

Cyanation is the attachment or substitution of a cyanide group on various substrates. Such transformations are...

Cycloaddition

A cycloaddition reaction indicates the addition of two π reactants to form a cyclic adduct with formation of σ bonds...

Darzens Reaction

Darzens reaction is also known as the Darzens condensation or glycidic ester condensation is the chemical reaction of...

Dearomatization

A dearomatization reaction is an organic reaction which involves arenes as reactants and in which the reaction...

Decarboxylation

Decarboxylation is the removal or loss of a carboxyl group from an organic compound. During the reaction carbon...

Desymmetrization

Any reaction that results in the loss of one or more symmetry elements, but especially the conversion of a prochiral...

diastereomeric excess

The diastereomeric excess (de) reflects the degree to which a sample contains one diastereomer in greater amounts than...

diastereomeric ratio

The diastereomeric ratio (dr) of the percent of one diastereomer in a mixture to that of the other diastereomer. For...

Diastereomers

Molecules with more than one stereocenter can be diastereomers if they are not mirror images of each other. The key...

Domino Reaction

The domino reaction is a time-resolved process in which two or more bond-forming reactions occur under similar...

enantiomeric excess

Enantiomeric excess is a measurement of purity used for chiral substances. It reflects the degree to which a sample...

enantiomeric ratio

The ratio of the percent of one enantiomer in a mixture to that of the other. Enantiomeric ratio of 7:3 means for...

Enantiomers

Enantiomers have identical chemical and physical properties and are indistinguishable from each other except for the...

Epoxidation

Epoxidation is treatment where an electrophilic oxidizing agent is capable of introducing a single oxygen atom to...

Fluorination

Fluorination is for instance a replacement of one hydrogen atom within a molecule by fluorine. The incorporation of...

Green Chemistry

Green chemistry is the design of chemical products and processes that reduce or eliminate the use or generation of...

Hydroarylation

Hydroarylation can be defined as the addition of an aryl group and a hydrogen atom across an unsaturated moiety...

Hydrogenation

Hydrogenation is a reduction reaction which results in an addition of hydrogen (often as H2). If an organic compound...

Hydrophosphonylation

Hydrophosphonylation refers to any reaction where addition across a double bond generates a phosphonate (RP(O)(OR')2)...

Hydroxylation

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. Hydroxylation...

Isomerization

Isomerization is a chemical process by which a compound is transformed into any of its isomeric forms, i.e., forms...

Mannich Reaction

The Mannich reaction is the aminoalkylation reaction, involving the condensation of an enolizable carbonyl compound...

Meso compounds

Molecules that exhibit achiral properties despite having stereogenic centers are called meso compounds. Meso forms...

Michael Addition

Michael addition (MA) is one of the most frequently used C-C bond-forming reactions in organic synthesis and is easily...

Nazarov Cyclization

Nazarov Cyclization is one of the most versatile methods for the synthesis of cyclopentenones from vinyl ketones. For...

Optical Rotation

Optical Rotation is the property displayed by chiral substances of rotating the plane of polarisation of polarised...

Oxaziridination

Oxaziridines are generally formed by the action of a peracid on a combination of a carbonyl compound and an amine,...

Oxosulfonylation

Oxosulfonylation is a difunctionalization where oxo and sulfonyl groups are introduced in one step to construct...

Pseudoenantiomers

Cinchona alkaloids exist in nature as pseudoenantiomers, which allow Cinchona alkaloid-catalyzed reactions to provide...

Quinidine

What is Quinidine? Quinidine is a cinchona alkaloid extracted from the bark of the cinchona tree. Quinidine is used as...

Racemate

A Racemate has equal amounts of left- and right-handed enantiomers of a chiral molecule.

Racemic Resolution

Racemic Resolution, also called optical resolution or chiral resolution, is a traditional widely-used process for the...

Reformatsky Reaction

Reformatsky Reaction is an organic reaction which condenses aldehydes or ketones with α-halo esters using metallic...

Sonogashira Coupling

The Sonogashira Reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It...

Strecker Synthesis

The Strecker amino acid synthesis, also known simply as the Strecker synthesis, is a method for the synthesis of amino...

Tamura Cyclization

In the presence of a Cinchona squaramide-based catalyst, enolizable anhydrides react with alkylidene oxindoles to...

Wolff Rearrangement

The Wolff Rearrangement allows the generation of ketenes from α-diazoketones. During this  reaction an α-diazocarbonyl...