Atropisomer Synthesis, substituted 4-acetyl-1-formamido-5-phenyl-1H-pyrrole-3-carboxylate, substituted 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate, N–N axially chiral compounds, Quinidine BaseAtropisomer synthesis Alkylation, cyclic N‐sulfonyl ketimines, malonic acid half thioesters, substituted 2-(1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-3-yl)ethanethioate, N-(9R)-cinchonan-9-yl-8-quinolinesulfonamide, Cinchonine DerivativeAlkylation, Alkylation, Mannich, Mannich Diels-Alder reaction, alkylidene pyrazolones, allyl ketones, tetrahydropyrano[2,3-c]pyrazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCycloaddition, Diels-Alder reaction Iodination, substituted pent-4-enal oxime, N-Iodsuccinimid, iodine, 3,6-disubstituted 6-(iodomethyl)-5,6-dihydro-4H-1,2-oxazine, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-yl-thiourea, Cinchonidine DerivativeIodination [3+2]-Cycloaddition, (E)-2-oxo-4-styryl-2H-chromene-3-carbonitrile, diethyl (E)-2-((2-hydroxybenzylidene)amino)malonate, diethyl (3R,4R,5S)-4-(3-cyano-2-oxo-2H-chromen-4-yl)-5-(2-hydroxyphenyl)-3-phenylpyrrolidine-2,2-dicarboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine Derivative[3+2]-Cycloaddition, Cycloaddition Oxa-Michael, (E)-1-(2-hydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)-4-((triisopropylsilyl)oxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (R)-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one, (8α,9R)-1-(9-anthracenylmethyl)-9-(2-propenyloxy)-cinchonanium bromide, Cinchonidine DerivativeMichael Addition, Oxa-Michael Addition Spirocyclization, N,N-dibenzyl-3-(chloromethyl)-4-(hydroxymethyl)benzenaminium chloride, methyl 1-(tert-butyl)-2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate, (R)-1′-(tert-butyl)-5-(dibenzylamino)-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-(9R)-cinchonanium bromide, Cinchonidine DerivativeSpirocyclization α-Alkylation of ketones, 6,7-dichloro-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, 1,3-dichlorobut-2-ene, (R,Z)-6,7-dichloro-2-(3-chlorobut-2-en-1-yl)-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, (8α,9R)-9-hydroxy-1-[[4-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation Dynamic kinetic Resolution, substituted 2-hydroxy-N,N-disubstituted-1-naphthamide, benzyl iodide, substituted 2-(benzyloxy)-N,N-disubstituted-1-naphthamide, (9S)-9-hydroxy-1-[[2,3′′,4,5′′-tetrakis(1,1-dimethylethyl)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeDynamic Kinetic Resolution, Resolution Baylis Hillman, (9H-fluoren-9-yl)methyl (S)-(4-methyl-1-oxopentan-2-yl)carbamate, 1,1,1,3,3,3-hexafluoropropan-2-yl acrylate, sodium methanolate, methyl (3S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-6-methyl-2-methyleneheptanoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeMorita-Baylis-Hillman (MBH)« Older EntriesNext Entries »
Atropisomer Synthesis, substituted 4-acetyl-1-formamido-5-phenyl-1H-pyrrole-3-carboxylate, substituted 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate, N–N axially chiral compounds, Quinidine BaseAtropisomer synthesis
Alkylation, cyclic N‐sulfonyl ketimines, malonic acid half thioesters, substituted 2-(1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-3-yl)ethanethioate, N-(9R)-cinchonan-9-yl-8-quinolinesulfonamide, Cinchonine DerivativeAlkylation, Alkylation, Mannich, Mannich
Diels-Alder reaction, alkylidene pyrazolones, allyl ketones, tetrahydropyrano[2,3-c]pyrazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCycloaddition, Diels-Alder reaction
Iodination, substituted pent-4-enal oxime, N-Iodsuccinimid, iodine, 3,6-disubstituted 6-(iodomethyl)-5,6-dihydro-4H-1,2-oxazine, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-yl-thiourea, Cinchonidine DerivativeIodination
[3+2]-Cycloaddition, (E)-2-oxo-4-styryl-2H-chromene-3-carbonitrile, diethyl (E)-2-((2-hydroxybenzylidene)amino)malonate, diethyl (3R,4R,5S)-4-(3-cyano-2-oxo-2H-chromen-4-yl)-5-(2-hydroxyphenyl)-3-phenylpyrrolidine-2,2-dicarboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine Derivative[3+2]-Cycloaddition, Cycloaddition
Oxa-Michael, (E)-1-(2-hydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)-4-((triisopropylsilyl)oxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (R)-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one, (8α,9R)-1-(9-anthracenylmethyl)-9-(2-propenyloxy)-cinchonanium bromide, Cinchonidine DerivativeMichael Addition, Oxa-Michael Addition
Spirocyclization, N,N-dibenzyl-3-(chloromethyl)-4-(hydroxymethyl)benzenaminium chloride, methyl 1-(tert-butyl)-2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate, (R)-1′-(tert-butyl)-5-(dibenzylamino)-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-(9R)-cinchonanium bromide, Cinchonidine DerivativeSpirocyclization
α-Alkylation of ketones, 6,7-dichloro-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, 1,3-dichlorobut-2-ene, (R,Z)-6,7-dichloro-2-(3-chlorobut-2-en-1-yl)-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, (8α,9R)-9-hydroxy-1-[[4-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation
Dynamic kinetic Resolution, substituted 2-hydroxy-N,N-disubstituted-1-naphthamide, benzyl iodide, substituted 2-(benzyloxy)-N,N-disubstituted-1-naphthamide, (9S)-9-hydroxy-1-[[2,3′′,4,5′′-tetrakis(1,1-dimethylethyl)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeDynamic Kinetic Resolution, Resolution
Baylis Hillman, (9H-fluoren-9-yl)methyl (S)-(4-methyl-1-oxopentan-2-yl)carbamate, 1,1,1,3,3,3-hexafluoropropan-2-yl acrylate, sodium methanolate, methyl (3S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-6-methyl-2-methyleneheptanoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeMorita-Baylis-Hillman (MBH)
