An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons.
DOI Number:
10.1039/c8ob00707a
Reaction Category:
Educt:
pyrazolamides, cyclic trifluoromethylketimines
Product:
(S)-6-chloro-1-(4-methoxybenzyl)-4-((S)-2-oxo-2-(1H-pyrazol-1-yl)-1-(p-tolyl)ethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0