An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons.

DOI Number:

10.1039/c8ob00707a

Reaction Category:

RXNO ID:

RXNO_0000032

Educt:

pyrazolamides, cyclic trifluoromethylketimines

Product:

(S)-6-chloro-1-(4-methoxybenzyl)-4-((S)-2-oxo-2-(1H-pyrazol-1-yl)-1-(p-tolyl)ethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Cas No:

130-95-0