N,N-Atropisomer synthesis, 2-phenylpropanal, di-tert-butyl (E)-diazene-1,2-dicarboxylate, (bromomethyl)benzene, di-tert-butyl (S)-1-benzyl-2-(1-oxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, (8α,9R)-9-hydroxy-6′-methoxy-1-(phenylmethyl)-Cinchonanium bromide, Quinine DerivativeAtropisomer synthesis Aza-Michael Addition, benzyl (E)-(7-oxooct-5-en-1-yl)carbamate, benzyl (R)-2-(2-oxopropyl)piperidine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition Dihydroxylation, methyl (E)-4-(2-iodo-6-methylphenyl)but-2-enoate, methyl (2R,3S)-2,3-dihydroxy-4-(2-iodo-6-methylphenyl)butanoate, Dipotassium osmate, (8α,9R)-10,11-dihydro-6′-methoxy-9-(9-phenanthrenyloxy)-Cinchonan, Dihydroquinine DerivativeDihydroxylation, Further reactions, Hydroxylation Aza-Friedel-Crafts reaction, tert-butyl (E)-(1-benzyl-2-oxoindolin-3-ylidene)carbamates, naphthols, tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxoindolin-3-yl)carbamates, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Thiourea (aminoalkyl polystyrene resin-supported), Dihydroquinine DerivativeAza-Friedel-Crafts, Friedel-Crafts Sulfa-Michael addition, 3-methylbenzenethiol, ethyl (Z)-2-fluoro-5-phenylpent-2-enoate, ethyl (2S,3S)-2-fluoro-5-phenyl-3-(m-tolylthio)pentanoate, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Cascade reaction, diethyl 2-bromomalonate, 4-arylidenepyrazol-5-ones, spirocyclopropylpyrazolones, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeCascade reaction, Spirocyclization Ugi-type reaction, α-aryl-substituted isocyanoacetates, C,N-cyclic azomethine imines, C1-oxazole-substituted tetrahydroisoquinolines, 3-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Ugi-type reaction Mannich reaction, α-isocyanoacetates, N-(2-benzothiazolyl)imines, benzothiazole-dihydroimidazoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich Aza-Michael Addition, tert-butyl (E)-(2-((4-oxopent-2-en-1-yl)oxy)ethyl)carbamate, tert-butyl (S)-3-(2-oxopropyl)morpholine-4-carboxylate, diphenyl hydrogenphosphate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition Aza-Michael Addition, benzyl (E)-((6-oxohept-4-en-1-yl)oxy)carbamate, benzyl (R)-3-(2-oxopropyl)-1,2-oxazinane-2-carboxylate, pentafluoropropionic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition« Older EntriesNext Entries »
N,N-Atropisomer synthesis, 2-phenylpropanal, di-tert-butyl (E)-diazene-1,2-dicarboxylate, (bromomethyl)benzene, di-tert-butyl (S)-1-benzyl-2-(1-oxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, (8α,9R)-9-hydroxy-6′-methoxy-1-(phenylmethyl)-Cinchonanium bromide, Quinine DerivativeAtropisomer synthesis
Aza-Michael Addition, benzyl (E)-(7-oxooct-5-en-1-yl)carbamate, benzyl (R)-2-(2-oxopropyl)piperidine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition
Dihydroxylation, methyl (E)-4-(2-iodo-6-methylphenyl)but-2-enoate, methyl (2R,3S)-2,3-dihydroxy-4-(2-iodo-6-methylphenyl)butanoate, Dipotassium osmate, (8α,9R)-10,11-dihydro-6′-methoxy-9-(9-phenanthrenyloxy)-Cinchonan, Dihydroquinine DerivativeDihydroxylation, Further reactions, Hydroxylation
Aza-Friedel-Crafts reaction, tert-butyl (E)-(1-benzyl-2-oxoindolin-3-ylidene)carbamates, naphthols, tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxoindolin-3-yl)carbamates, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Thiourea (aminoalkyl polystyrene resin-supported), Dihydroquinine DerivativeAza-Friedel-Crafts, Friedel-Crafts
Sulfa-Michael addition, 3-methylbenzenethiol, ethyl (Z)-2-fluoro-5-phenylpent-2-enoate, ethyl (2S,3S)-2-fluoro-5-phenyl-3-(m-tolylthio)pentanoate, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Cascade reaction, diethyl 2-bromomalonate, 4-arylidenepyrazol-5-ones, spirocyclopropylpyrazolones, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeCascade reaction, Spirocyclization
Ugi-type reaction, α-aryl-substituted isocyanoacetates, C,N-cyclic azomethine imines, C1-oxazole-substituted tetrahydroisoquinolines, 3-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Ugi-type reaction
Mannich reaction, α-isocyanoacetates, N-(2-benzothiazolyl)imines, benzothiazole-dihydroimidazoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich
Aza-Michael Addition, tert-butyl (E)-(2-((4-oxopent-2-en-1-yl)oxy)ethyl)carbamate, tert-butyl (S)-3-(2-oxopropyl)morpholine-4-carboxylate, diphenyl hydrogenphosphate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition
Aza-Michael Addition, benzyl (E)-((6-oxohept-4-en-1-yl)oxy)carbamate, benzyl (R)-3-(2-oxopropyl)-1,2-oxazinane-2-carboxylate, pentafluoropropionic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition
