Asymmetric Synthesis of CF3-and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael–Aldol Reaction.
DOI Number:
10.1021/acs.orglett.6b01498
Reaction Category:
Educt:
substituted (E)-3-trifluoromethyl-3-(1H-indol-3-yl)-1-phenylprop-2-en-1-one, substituted 2-mercaptobenzaldehyde
Product:
substituted ((2R,3S,4R)-4-hydroxy-2-((S)-indolin-3-yl)-2-(trifluoromethyl)thiochroman-3-yl)(phenyl)methanone
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-86-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2