Chiral Bifunctional Amine-Squaramide-Catalyzed Highly Diastereo-and Enantioselective Michael/Aldol Cascade Reaction of 2-Mercaptobenzaldehyde and α, β-Unsaturated 7-Azaindoline Amides.
DOI Number:
10.1021/acs.joc.9b00837
Reaction Category:
Educt:
substituted 2-mercaptobenzaldehyde, substituted 1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)prop-2-en-1-one
Product:
substituted (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)((3S,4R)-4-hydroxythiochroman-3-yl)methanone
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione
Cas No:
1256245-86-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2