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Alkylation, alpha-monosubstituted malonic diesters, alkyl dihalides, alpha,alpha-disubstituted malonic diesters, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride, Cinchonine Derivative

Alkylation, Alkylation

Annulation of alkyl dihalides, oxindoles, alkyl dihalides, spiropentyl oxindoles, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-(((tert-butoxycarbonyl)-D-valyl)oxy)(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine Derivative

Spirocyclization

Oxohydroxylation, alpha-alkyl enoates, potassium permanganate, alpha-hydroxy-beta-ketoesters, (1S,2R,4S,5R)-2-((S)-((2-bromo-3,5-di-tert-butylbenzyl)oxy)(quinolin-4-yl)methyl)-1-(3,5-difluorobenzyl)-5-vinylquinuclidin-1-ium, Cinchonine Derivative

Further reactions, Oxohydroxylation

Michael Addition, (E)-1-fluoro-4-(2-nitrovinyl)benzene, dimethyl malonate, dimethyl (R)-2-(1-(4-fluorophenyl)-2-nitroethyl)malonate, 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea, Cinchonine Derivative

Michael, Michael Addition

Dynamic kinetic resolution, 2-formylbenzoic acid, phthalidyl esters, Cinchonine Base

Dynamic Kinetic Resolution, Resolution

Aza-Michael Addition, substituted (E)-chalcone, substituted aniline, substituted aromatic beta-amino ketones, trimethylsilylhalides, Cinchonine Base

Aza-Michael, Michael Addition

1,3-Dipolar Cycloaddition, 2,6-bis(arylmethylidene) cyclohexanones, azomethine ylides, spirocyclohexanone-pyrrolidine derivatives, Cinchonine Base

1,3-Dipolar Cycloaddition, Cycloaddition, Spirocyclization

Michael Addition, 3-Monosubstituted Oxindoles, (E)-1,4-Diaryl-2-buten-1,4-diones, tert-butyl (R)-3-((S)-1,4-diargio-1,4-dioxobutan-2-yl)-5-substituted-2-oxo-3-substituted-indoline-1-carboxylate, Cinchonine Base

Michael, Michael Addition

Michael Addition, beta-ketoester, tert-butyl 2-(trifluoromethyl)acrylate, 5-(tert-butyl) 1-substituted (S)-2-substitutedcarbonyl-2-substituted-4-(trifluoromethyl)-4lambda3-pentanedioate, Cinchonine Base

Michael, Michael Addition

Mannich reaction, beta-ketoester, acyl imines, substituted (S)-2-((S)-aryl((substitutedoxycarbonyl)amino)methyl)-3-oxobutanoate, Cinchonine Base

Mannich, Mannich

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