Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine.
DOI Number:
10.1021/ol800108u
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
(E)-1-fluoro-4-(2-nitrovinyl)benzene, dimethyl malonate
Product:
dimethyl (R)-2-(1-(4-fluorophenyl)-2-nitroethyl)malonate
Catalyst:
1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea
Cas No:
851477-19-5
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5