Aldol reaction, aldehydes, 2-fluoro-2H-benzo[d][1,3]dithiole 1,1,3,3-tetraoxide, primary 2-fluoroalcohols, tetraisopropoxytitanium, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-hydroxycinchonan-9-yl]-thiourea, Cupreine DerivativeAldol, Aldol, Fluorination, Fluoromethylation Aza-Michael-Aldol cascade, (E)-4-substituted-but-3-en-2-one, substituted methyl 2-oxo-2-(1H-pyrrol-2-yl)acetate, 3,5,6-trisubstituted methyl (1R,2R,3R)-2-acetyl-1-hydroxy-2,3-dihydro-1H-pyrrolizine-1-carboxylate, (8α,9S)-6′-(2,2-dimethylpropoxy)-Cinchonan-9-amine, Cupreine DerivativeAldol, Aldol, Aza-Michael, Cascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael Addition Michael addition, Spirocyclization, tert-butyl 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (vinylselenonyl)benzene, (S)-5′,6′-dimethoxy-4,5-dihydro-2H-spiro[furan-3,2′-indene]-1′,2(3’H)-dione, (8α,9R)-9-(1-phenanthrenyloxy)-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Lactonization, Michael, Michael Addition, Spirocyclization vinylogous α-ketol rearrangement, substituted 3-(1-hydroxycyclobutyl)cyclohex-2-en-1-one, substituted (S)-spiro[4.5]decane-1,7-dione, (8α,9S)-9-amino-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Spirocyclization vinylogous Mannich reaction, tert-butyl ((3-chlorophenyl)(phenylsulfonyl)methyl)carbamate, 2-(thiochroman-4-ylidene)malononitrile, tert-butyl ((S)-(3-chlorophenyl)((S)-4-(dicyanomethylene)thiochroman-3-yl)methyl)carbamate, (8α,9R)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonidine DerivativeMannich, Mannich Henry reaction, aldehydes, nitromethane, 1-substituted (R)-2-nitroethan-1-ol, 9-([2,2′-bipyridin]-6-yloxy)-6′-methoxy-cinchonan, Quinine DerivativeAldol, Henry, Henry, Nitroaldol Spirocyclization, substituted (E)-4-ethylideneisoxazol-5(4H)-one, substituted 2-cyanoacetate, substituted (3S,4S,5S)-6-oxo-7-oxa-1,8-diazaspiro[4.4]non-8-ene-3-carboxylate, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Spirocyclization Asymmetric desymmetrization, 2,6-disubstituted 4,6-dichloro-5-phenylpyrimidine, benzenethiol, 2,6 disubstituted (r)-4-chloro-5-phenyl-6-(phenylthio)pyrimidine, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAtropisomer synthesis, Desymmetrization Mannich reaction, benzyl ((4-methoxyphenyl)(tosyl)methyl)carbamate, bis(4-methoxyphenyl) malonate, bis(4-methoxyphenyl) (S)-2-((((benzyloxy)carbonyl)amino)(4-methoxyphenyl)methyl)malonate, 9-hydroxy-6′-methoxy-1-[[2-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Quinine DerivativeMannich, Mannich Aza-Henry, Nitro-Mannich, substituted tert-butyl (tosylmethyl)carbamate, primary nitroalkanes, 1,2-substituted tert-butyl ((1R,2S)-2-nitroethyl)carbamate, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich« Older EntriesNext Entries »
Aldol reaction, aldehydes, 2-fluoro-2H-benzo[d][1,3]dithiole 1,1,3,3-tetraoxide, primary 2-fluoroalcohols, tetraisopropoxytitanium, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-hydroxycinchonan-9-yl]-thiourea, Cupreine DerivativeAldol, Aldol, Fluorination, Fluoromethylation
Aza-Michael-Aldol cascade, (E)-4-substituted-but-3-en-2-one, substituted methyl 2-oxo-2-(1H-pyrrol-2-yl)acetate, 3,5,6-trisubstituted methyl (1R,2R,3R)-2-acetyl-1-hydroxy-2,3-dihydro-1H-pyrrolizine-1-carboxylate, (8α,9S)-6′-(2,2-dimethylpropoxy)-Cinchonan-9-amine, Cupreine DerivativeAldol, Aldol, Aza-Michael, Cascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael Addition
Michael addition, Spirocyclization, tert-butyl 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (vinylselenonyl)benzene, (S)-5′,6′-dimethoxy-4,5-dihydro-2H-spiro[furan-3,2′-indene]-1′,2(3’H)-dione, (8α,9R)-9-(1-phenanthrenyloxy)-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Lactonization, Michael, Michael Addition, Spirocyclization
vinylogous α-ketol rearrangement, substituted 3-(1-hydroxycyclobutyl)cyclohex-2-en-1-one, substituted (S)-spiro[4.5]decane-1,7-dione, (8α,9S)-9-amino-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Spirocyclization
vinylogous Mannich reaction, tert-butyl ((3-chlorophenyl)(phenylsulfonyl)methyl)carbamate, 2-(thiochroman-4-ylidene)malononitrile, tert-butyl ((S)-(3-chlorophenyl)((S)-4-(dicyanomethylene)thiochroman-3-yl)methyl)carbamate, (8α,9R)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonidine DerivativeMannich, Mannich
Henry reaction, aldehydes, nitromethane, 1-substituted (R)-2-nitroethan-1-ol, 9-([2,2′-bipyridin]-6-yloxy)-6′-methoxy-cinchonan, Quinine DerivativeAldol, Henry, Henry, Nitroaldol
Spirocyclization, substituted (E)-4-ethylideneisoxazol-5(4H)-one, substituted 2-cyanoacetate, substituted (3S,4S,5S)-6-oxo-7-oxa-1,8-diazaspiro[4.4]non-8-ene-3-carboxylate, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Spirocyclization
Asymmetric desymmetrization, 2,6-disubstituted 4,6-dichloro-5-phenylpyrimidine, benzenethiol, 2,6 disubstituted (r)-4-chloro-5-phenyl-6-(phenylthio)pyrimidine, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAtropisomer synthesis, Desymmetrization
Mannich reaction, benzyl ((4-methoxyphenyl)(tosyl)methyl)carbamate, bis(4-methoxyphenyl) malonate, bis(4-methoxyphenyl) (S)-2-((((benzyloxy)carbonyl)amino)(4-methoxyphenyl)methyl)malonate, 9-hydroxy-6′-methoxy-1-[[2-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Quinine DerivativeMannich, Mannich
Aza-Henry, Nitro-Mannich, substituted tert-butyl (tosylmethyl)carbamate, primary nitroalkanes, 1,2-substituted tert-butyl ((1R,2S)-2-nitroethyl)carbamate, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
