Enantioselective organocatalytic approaches to active pharmaceutical ingredients – selected industrial examples.
DOI Number:
10.1515/psr-2018-0097; Patent WO2017218920A1
Reaction Category:
RXNO ID:
RXNO_0000016
Educt:
3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one, paraformaldehyde
Product:
(S)-3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-3-(hydroxymethyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one
Catalyst:
N-[3,5-bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]-Thiourea
Cas No:
852913-19-0
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7