Asymmetric multicomponent sulfa-Michael/Mannich cascade reaction: synthetic access to 1, 2-diamino-3-organosulfur compounds and 2-nitro allylic amines.

DOI Number:

10.1021/acs.orglett.5b02423

Reaction Category:

RXNO ID:

RXNO_0000032

Educt:

arylic thiols, arylic (E)-nitroethene, arylic (E)-4-methyl-N-methylenebenzenesulfonamide

Product:

1,3 substituted N-((1R,2S,3S)-3-(arylthio)-2-nitropropyl)-4-methylbenzenesulfonamide

Catalyst:

N-[(1R,2S)-2-(1,1-dimethylethoxy)-1-[[[[[(8α,9R)-9-(phenylmethoxy)cinchonan-6′-yl]amino]thioxomethyl]amino]methyl]propyl]-4-methyl-benzenesulfonamide

Cas No:

1809547-69-0

Cas No:

2143936-34-7