Spirocyclization, 3-(3,5-dihydroxy-4-methoxyphenethyl)cyclohex-2-en-1-one, (S)-5′,7′-dihydroxy-6′-methoxy-2′,3′-dihydrospiro[cyclohexane-1,1′-inden]-3-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeSpirocyclization α-Alkylation, ethyl 2-((diphenylmethylene)amino)acetate, halogenides, ethyl 2-substituted-2-((diphenylmethylene)amino)acetate, (1R,2R,4S,5R)-2-((S)-hydroxy(quinolin-4-yl)methyl)-1-(3-((2,20,25,35-tetra-tert-butyl-32-(2-ethoxy-2-oxoethoxy)-6,7,9,10,12,13,15,16-octahydro-22H,28H-4,18-(methano[1,3]benzenomethano)-23,27-(metheno)dibenzo[n,w][1,4,7,10,13]pentaoxacyclotetracosin-29-yl)oxy)propyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation Amination, substituted tert-butyl ((4-oxo-4H-chromen-3-yl)methyl) carbonate, primary amines, substituted (Z)-3-(((arylmethyl)amino)methylene)chroman-4-one, (2S,3S)-2-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(8α,9S)-cinchonan-9-yl-3-methyl-pentanamide, Cinchonidine DerivativeAmination Amination, substituted ethyl (Z)-3-(2-oxoindolin-3-ylidene)butanoate, (E)-diazene-1,2-dicarboxylic acid ester, substituted (R,Z)-1-(1-ethoxy-1-oxo-3-(2-oxoindolin-3-ylidene)butan-2-yl)hydrazine-1,2-dicarboxylic acid ester, (8α,9R)-9-(Phenylmethoxy)cinchonan, Cinchonidine Derivativealpha-Amination, Amination Michael Addition, α,β-unsaturated ketones, nitroalkanes, γ-nitroketones, (8α,9S)-N-[(1R,2R)-2-Aminocyclohexyl]-N′-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael, Michael Addition Epoxidation, 2-isopropylnaphthalene-1,4-dione, hydrogen peroxide, (1aS,7aR)-1a-isopropyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione, (9S)-1-(9-anthracenylmethyl)-9-hydroxy-cinchonanium chloride, Cinchonine DerivativeEpoxidation Aldol reaction, 1-naphthalenecarboxaldehyde, tert-butyl diazoacetate, 1,1-dimethylethyl (βS)-α-diazo-β-hydroxybenzenepropanoate, (8α,9R)- 1-(9-anthracenylmethyl)- 9-hydroxy-Cinchonanium chloride, Cinchonidine DerivativeAldol, Aldol Alkylation, o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester, 3-bromoprop-1-ene, (bromomethyl)benzene, substituited o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester, 1-(9-anthracenylmethyl)-9-(2-propenyloxy)-(8α,9R)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation Aziridination, 1-((4R,7S)-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)prop-2-en-1-one, N-chloro-N-sodiocarbamates, benzyl (S)-2-((4R,7S)-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole-1-carbonyl)aziridine-1-carboxylate, 1-(9-anthracenylmethyl)-9-(2-propenyloxy)-(8α,9R)-cinchonanium bromide, Cinchonidine DerivativeAziridination Spirocyclization, substituted cyclopent-2-en-1-one, substituted isoxazol-5(4H)-one, aldehydes, substituted tetrahydro-4’H,5H-spiro[isoxazole-4,2′-pentalene]-4′,5-dione, 4-methylsalicylic acid, (8α,9S)-2′-(1,1-Dimethylethyl)cinchonan-9-amine, Cinchonidine DerivativeSpirocyclization« Older EntriesNext Entries »
Spirocyclization, 3-(3,5-dihydroxy-4-methoxyphenethyl)cyclohex-2-en-1-one, (S)-5′,7′-dihydroxy-6′-methoxy-2′,3′-dihydrospiro[cyclohexane-1,1′-inden]-3-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeSpirocyclization
α-Alkylation, ethyl 2-((diphenylmethylene)amino)acetate, halogenides, ethyl 2-substituted-2-((diphenylmethylene)amino)acetate, (1R,2R,4S,5R)-2-((S)-hydroxy(quinolin-4-yl)methyl)-1-(3-((2,20,25,35-tetra-tert-butyl-32-(2-ethoxy-2-oxoethoxy)-6,7,9,10,12,13,15,16-octahydro-22H,28H-4,18-(methano[1,3]benzenomethano)-23,27-(metheno)dibenzo[n,w][1,4,7,10,13]pentaoxacyclotetracosin-29-yl)oxy)propyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation
Amination, substituted tert-butyl ((4-oxo-4H-chromen-3-yl)methyl) carbonate, primary amines, substituted (Z)-3-(((arylmethyl)amino)methylene)chroman-4-one, (2S,3S)-2-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(8α,9S)-cinchonan-9-yl-3-methyl-pentanamide, Cinchonidine DerivativeAmination
Amination, substituted ethyl (Z)-3-(2-oxoindolin-3-ylidene)butanoate, (E)-diazene-1,2-dicarboxylic acid ester, substituted (R,Z)-1-(1-ethoxy-1-oxo-3-(2-oxoindolin-3-ylidene)butan-2-yl)hydrazine-1,2-dicarboxylic acid ester, (8α,9R)-9-(Phenylmethoxy)cinchonan, Cinchonidine Derivativealpha-Amination, Amination
Michael Addition, α,β-unsaturated ketones, nitroalkanes, γ-nitroketones, (8α,9S)-N-[(1R,2R)-2-Aminocyclohexyl]-N′-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael, Michael Addition
Epoxidation, 2-isopropylnaphthalene-1,4-dione, hydrogen peroxide, (1aS,7aR)-1a-isopropyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione, (9S)-1-(9-anthracenylmethyl)-9-hydroxy-cinchonanium chloride, Cinchonine DerivativeEpoxidation
Aldol reaction, 1-naphthalenecarboxaldehyde, tert-butyl diazoacetate, 1,1-dimethylethyl (βS)-α-diazo-β-hydroxybenzenepropanoate, (8α,9R)- 1-(9-anthracenylmethyl)- 9-hydroxy-Cinchonanium chloride, Cinchonidine DerivativeAldol, Aldol
Alkylation, o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester, 3-bromoprop-1-ene, (bromomethyl)benzene, substituited o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester, 1-(9-anthracenylmethyl)-9-(2-propenyloxy)-(8α,9R)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation
Aziridination, 1-((4R,7S)-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)prop-2-en-1-one, N-chloro-N-sodiocarbamates, benzyl (S)-2-((4R,7S)-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole-1-carbonyl)aziridine-1-carboxylate, 1-(9-anthracenylmethyl)-9-(2-propenyloxy)-(8α,9R)-cinchonanium bromide, Cinchonidine DerivativeAziridination
Spirocyclization, substituted cyclopent-2-en-1-one, substituted isoxazol-5(4H)-one, aldehydes, substituted tetrahydro-4’H,5H-spiro[isoxazole-4,2′-pentalene]-4′,5-dione, 4-methylsalicylic acid, (8α,9S)-2′-(1,1-Dimethylethyl)cinchonan-9-amine, Cinchonidine DerivativeSpirocyclization
