Sulfa-Michael Addition, trisubstituted nitroalkenes, thioacids, 1,2-nitrothioacetates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Biginelli reaction, α,β-unsaturated aldehydes, thiourea, β-ketoesters, 3,4-dihydro-pyrimidin-2-(1H)-thiones, trans-4,5-methano-L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions Cyanation, α-ketiminophosphonates, acetyl cyanide, tetrasubstituted α-phosphono-α-amino nitriles, Cinchonidine BaseCyanation Knoevenagel reaction, aldehydes, 2-(phenylsulfonyl)acetonitrile, substituted benzene-1,2-diamine, substituted 3,4-dihydroquinoxalin-2(1H)-one, cumene hydroperoxide, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea, Quinine DerivativeEpoxidation, Knoevenagel Michael Addition, (E)-(2-nitrovinyl)benzene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, silver(I)acetate, 3-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-(phenylamino)-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Michael Addition, nitrostyrenes, α-alkylidene succinimides, substituted tert-butyl (R)-3-methylene-4-(2-nitroethyl)-2,5-dioxopyrrolidine-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Amination, 1-cyclohexenylaldehyde, di-tert-butyl azodicarboxylate, 1,2-Bis(1,1-dimethylethyl) 1-[(1S)-1-formyl-2-cyclohexen-1-yl]-1,2-hydrazinedicarboxylate, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeAmination Sulfonylation, (2E)-1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-buten-1-one, 3,5-Diethyl 4-cyclohexyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, DABCO-bis(sulfur dioxide), (3S)-3-(cyclohexylsulfonyl)-1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-butanone, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Sulfonylation Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH) Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization« Older EntriesNext Entries »
Sulfa-Michael Addition, trisubstituted nitroalkenes, thioacids, 1,2-nitrothioacetates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Biginelli reaction, α,β-unsaturated aldehydes, thiourea, β-ketoesters, 3,4-dihydro-pyrimidin-2-(1H)-thiones, trans-4,5-methano-L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions
Cyanation, α-ketiminophosphonates, acetyl cyanide, tetrasubstituted α-phosphono-α-amino nitriles, Cinchonidine BaseCyanation
Knoevenagel reaction, aldehydes, 2-(phenylsulfonyl)acetonitrile, substituted benzene-1,2-diamine, substituted 3,4-dihydroquinoxalin-2(1H)-one, cumene hydroperoxide, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea, Quinine DerivativeEpoxidation, Knoevenagel
Michael Addition, (E)-(2-nitrovinyl)benzene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, silver(I)acetate, 3-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-(phenylamino)-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Michael Addition, nitrostyrenes, α-alkylidene succinimides, substituted tert-butyl (R)-3-methylene-4-(2-nitroethyl)-2,5-dioxopyrrolidine-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Amination, 1-cyclohexenylaldehyde, di-tert-butyl azodicarboxylate, 1,2-Bis(1,1-dimethylethyl) 1-[(1S)-1-formyl-2-cyclohexen-1-yl]-1,2-hydrazinedicarboxylate, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeAmination
Sulfonylation, (2E)-1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-buten-1-one, 3,5-Diethyl 4-cyclohexyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, DABCO-bis(sulfur dioxide), (3S)-3-(cyclohexylsulfonyl)-1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-butanone, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Sulfonylation
Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH)
Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
