Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (S)-N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methoxyquinolin-4-yl)-1-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine, Quinine DerivativeHydrogenation, Hydrogenation of beta-ketoesters Michael Addition, vinylsulfones, diethyl (nitromethyl)phosphonates, (R)-substituted diethyl (1-nitro-3-(arylsulfonyl)propyl)phosphonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Cascade reaction, α,β-unsaturated-β-hydroxyketones, nitroalkenes, substituted dihydropyrane, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Spirocyclization, 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one, substituted 2-(2-oxoindolin-3-ylidene)acetonitrile, spirocyclic compounds, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization α-benzoyloxylation, aldehydes, benzoyl peroxide, (2S)-substituted 1-oxopropan-2-yl benzoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Hydroxymethylation, Further reactions Mannich reaction, isatin derived ketimines, acetylacetone, substituted (S)-(3-(2,4-dioxopentan-3-yl)-2-oxoindolin-3-yl)carbamate, 3-[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-2-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Michael Addition, α-nitrophosphonates, aryl acrylates, α-substituted α-nitrophosphonates, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Michael Addition, α,β‐unsaturated acyl pyrazoles, benzyl 2-nitroacetate, hydrogen, (S)-4-nitro-3-phenyl-1-(1H-pyrazol-1-yl)butan-1-one, palladium, 3,4-Bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Oxa-Michael, substituted 5-methylenethiazol-4-one, substituted 3-(propan-2-ylidene)indolin-2-one, thiazolopyran derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [(8α,9S)-cinchonan-9-ylamino]- 3-Cyclobutene-1,2-dione, Cinchonidine DerivativeMichael Addition, Oxa-Michael Addition, Vinylogous Michael Addition Cyclization, 2,3-dioxopyrrolidines, allyl aryl ketones, substituted (S)-2-(6-benzyl-7-oxo-2,3,4,5,6,7-hexahydropyrano[2,3-c]pyrrol-2-yl)acetaldehyde, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Cycloaddition« Older EntriesNext Entries »
Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (S)-N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methoxyquinolin-4-yl)-1-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine, Quinine DerivativeHydrogenation, Hydrogenation of beta-ketoesters
Michael Addition, vinylsulfones, diethyl (nitromethyl)phosphonates, (R)-substituted diethyl (1-nitro-3-(arylsulfonyl)propyl)phosphonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Cascade reaction, α,β-unsaturated-β-hydroxyketones, nitroalkenes, substituted dihydropyrane, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Spirocyclization, 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one, substituted 2-(2-oxoindolin-3-ylidene)acetonitrile, spirocyclic compounds, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization
α-benzoyloxylation, aldehydes, benzoyl peroxide, (2S)-substituted 1-oxopropan-2-yl benzoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Hydroxymethylation, Further reactions
Mannich reaction, isatin derived ketimines, acetylacetone, substituted (S)-(3-(2,4-dioxopentan-3-yl)-2-oxoindolin-3-yl)carbamate, 3-[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-2-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Michael Addition, α-nitrophosphonates, aryl acrylates, α-substituted α-nitrophosphonates, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Michael Addition, α,β‐unsaturated acyl pyrazoles, benzyl 2-nitroacetate, hydrogen, (S)-4-nitro-3-phenyl-1-(1H-pyrazol-1-yl)butan-1-one, palladium, 3,4-Bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Oxa-Michael, substituted 5-methylenethiazol-4-one, substituted 3-(propan-2-ylidene)indolin-2-one, thiazolopyran derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [(8α,9S)-cinchonan-9-ylamino]- 3-Cyclobutene-1,2-dione, Cinchonidine DerivativeMichael Addition, Oxa-Michael Addition, Vinylogous Michael Addition
Cyclization, 2,3-dioxopyrrolidines, allyl aryl ketones, substituted (S)-2-(6-benzyl-7-oxo-2,3,4,5,6,7-hexahydropyrano[2,3-c]pyrrol-2-yl)acetaldehyde, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Cycloaddition
