Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids.

DOI Number:

10.1021/jacs.7b09124

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

1-Methyl-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 1-(3-Methylphenyl)-2-propen-1-one

Product:

(5R)-1-Methyl-5-[3-(3-methylphenyl)-3-oxopropyl]-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione

Catalyst:

3-[[3-[bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl]-5-(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

2127845-72-9

Cas No:

130-95-0