Synthesis of Spiro-Δ2-Pyrrolin-4-One Pseudo Enantiomers via an Organocatalyzed Sulfa-Michael/Aldol Domino Sequence.

DOI Number:

10.1002/adsc.201900747

Reaction Category:

Educt:

methyl (5E)-4,5-dihydro-1,2-dimethyl-4-oxo-5-(phenylmethylene)-1H-pyrrole-3-carboxylate, 1,4-dithiane-2,5-diol

Product:

methyl (5S,6R,9S)-9-hydroxy-1,2-dimethyl-4-oxo-6-phenyl-7-thia-1-azaspiro[4.4]non-2-ene-3-carboxylate

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7