Buchler Glossary

1,4-Addition (conjugate addition)

The Michael reaction is the conjugate 1,4-Addition of a resonance stabilized carbanion (michael donor) to an activated α,β-unsaturated compound (michael acceptor).

Please find some examples of 1,4-Additions promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.

Further Articles:

Alkynylation

Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...

Allylsilylations

Allylsilylations are performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...

Aminohydroxylation

The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...