α-Alkylation of ketones, 6,7-dichloro-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, 1,3-dichlorobut-2-ene, (R,Z)-6,7-dichloro-2-(3-chlorobut-2-en-1-yl)-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, (8α,9R)-9-hydroxy-1-[[4-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation Dynamic kinetic Resolution, substituted 2-hydroxy-N,N-disubstituted-1-naphthamide, benzyl iodide, substituted 2-(benzyloxy)-N,N-disubstituted-1-naphthamide, (9S)-9-hydroxy-1-[[2,3′′,4,5′′-tetrakis(1,1-dimethylethyl)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeDynamic Kinetic Resolution, Resolution Baylis Hillman, (9H-fluoren-9-yl)methyl (S)-(4-methyl-1-oxopentan-2-yl)carbamate, 1,1,1,3,3,3-hexafluoropropan-2-yl acrylate, sodium methanolate, methyl (3S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-6-methyl-2-methyleneheptanoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeMorita-Baylis-Hillman (MBH) Michael Addition, 1,3-dicarbonyl compounds, β-fluoroalkyl-α-nitroalkenes, substituted 2-(2-nitroethyl)-propane-1,3-dione, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeMichael, Michael Addition Mannich reaction, 3-fluorooxindoles, cyclic N-sulfamidate aldimines, substituted (R)-3-((R)-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-fluoroindolin-2-one, (9S)-9-(phenylmethoxy)-cinchonan-6′-ol, Cupreidine DerivativeMannich, Mannich α-Alkylation, tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, tridecafluoro-6-iodohexane, tert-butyl (S)-1-oxo-2-(perfluorohexyl)-2,3-dihydro-1H-indene-2-carboxylate, (9S)-9-hydroxy-2′-[4-(trifluoromethyl)phenyl]-1-[(3,4,5-trifluorophenyl)methyl]-cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation Spirocyclization, 3-(3,5-dihydroxy-4-methoxyphenethyl)cyclohex-2-en-1-one, (S)-5′,7′-dihydroxy-6′-methoxy-2′,3′-dihydrospiro[cyclohexane-1,1′-inden]-3-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeSpirocyclization α-Alkylation, ethyl 2-((diphenylmethylene)amino)acetate, halogenides, ethyl 2-substituted-2-((diphenylmethylene)amino)acetate, (1R,2R,4S,5R)-2-((S)-hydroxy(quinolin-4-yl)methyl)-1-(3-((2,20,25,35-tetra-tert-butyl-32-(2-ethoxy-2-oxoethoxy)-6,7,9,10,12,13,15,16-octahydro-22H,28H-4,18-(methano[1,3]benzenomethano)-23,27-(metheno)dibenzo[n,w][1,4,7,10,13]pentaoxacyclotetracosin-29-yl)oxy)propyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation Amination, substituted tert-butyl ((4-oxo-4H-chromen-3-yl)methyl) carbonate, primary amines, substituted (Z)-3-(((arylmethyl)amino)methylene)chroman-4-one, (2S,3S)-2-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(8α,9S)-cinchonan-9-yl-3-methyl-pentanamide, Cinchonidine DerivativeAmination Amination, substituted ethyl (Z)-3-(2-oxoindolin-3-ylidene)butanoate, (E)-diazene-1,2-dicarboxylic acid ester, substituted (R,Z)-1-(1-ethoxy-1-oxo-3-(2-oxoindolin-3-ylidene)butan-2-yl)hydrazine-1,2-dicarboxylic acid ester, (8α,9R)-9-(Phenylmethoxy)cinchonan, Cinchonidine Derivativealpha-Amination, Amination« Older EntriesNext Entries »
α-Alkylation of ketones, 6,7-dichloro-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, 1,3-dichlorobut-2-ene, (R,Z)-6,7-dichloro-2-(3-chlorobut-2-en-1-yl)-5-methoxy-2-propyl-2,3-dihydro-1H-inden-1-one, (8α,9R)-9-hydroxy-1-[[4-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation
Dynamic kinetic Resolution, substituted 2-hydroxy-N,N-disubstituted-1-naphthamide, benzyl iodide, substituted 2-(benzyloxy)-N,N-disubstituted-1-naphthamide, (9S)-9-hydroxy-1-[[2,3′′,4,5′′-tetrakis(1,1-dimethylethyl)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeDynamic Kinetic Resolution, Resolution
Baylis Hillman, (9H-fluoren-9-yl)methyl (S)-(4-methyl-1-oxopentan-2-yl)carbamate, 1,1,1,3,3,3-hexafluoropropan-2-yl acrylate, sodium methanolate, methyl (3S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-6-methyl-2-methyleneheptanoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeMorita-Baylis-Hillman (MBH)
Michael Addition, 1,3-dicarbonyl compounds, β-fluoroalkyl-α-nitroalkenes, substituted 2-(2-nitroethyl)-propane-1,3-dione, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeMichael, Michael Addition
Mannich reaction, 3-fluorooxindoles, cyclic N-sulfamidate aldimines, substituted (R)-3-((R)-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-fluoroindolin-2-one, (9S)-9-(phenylmethoxy)-cinchonan-6′-ol, Cupreidine DerivativeMannich, Mannich
α-Alkylation, tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, tridecafluoro-6-iodohexane, tert-butyl (S)-1-oxo-2-(perfluorohexyl)-2,3-dihydro-1H-indene-2-carboxylate, (9S)-9-hydroxy-2′-[4-(trifluoromethyl)phenyl]-1-[(3,4,5-trifluorophenyl)methyl]-cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation
Spirocyclization, 3-(3,5-dihydroxy-4-methoxyphenethyl)cyclohex-2-en-1-one, (S)-5′,7′-dihydroxy-6′-methoxy-2′,3′-dihydrospiro[cyclohexane-1,1′-inden]-3-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeSpirocyclization
α-Alkylation, ethyl 2-((diphenylmethylene)amino)acetate, halogenides, ethyl 2-substituted-2-((diphenylmethylene)amino)acetate, (1R,2R,4S,5R)-2-((S)-hydroxy(quinolin-4-yl)methyl)-1-(3-((2,20,25,35-tetra-tert-butyl-32-(2-ethoxy-2-oxoethoxy)-6,7,9,10,12,13,15,16-octahydro-22H,28H-4,18-(methano[1,3]benzenomethano)-23,27-(metheno)dibenzo[n,w][1,4,7,10,13]pentaoxacyclotetracosin-29-yl)oxy)propyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation
Amination, substituted tert-butyl ((4-oxo-4H-chromen-3-yl)methyl) carbonate, primary amines, substituted (Z)-3-(((arylmethyl)amino)methylene)chroman-4-one, (2S,3S)-2-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(8α,9S)-cinchonan-9-yl-3-methyl-pentanamide, Cinchonidine DerivativeAmination
Amination, substituted ethyl (Z)-3-(2-oxoindolin-3-ylidene)butanoate, (E)-diazene-1,2-dicarboxylic acid ester, substituted (R,Z)-1-(1-ethoxy-1-oxo-3-(2-oxoindolin-3-ylidene)butan-2-yl)hydrazine-1,2-dicarboxylic acid ester, (8α,9R)-9-(Phenylmethoxy)cinchonan, Cinchonidine Derivativealpha-Amination, Amination
