Asymmetric Synthesis of Spiro-3, 3′-cyclopropyl Oxindoles via Vinylogous Michael Initiated Ring Closure Reaction.
DOI Number:
10.1021/acs.joc.2c02402
Reaction Category:
Educt:
substituted 2-(2-oxoindolin-3-ylidene)malonate ester, substituted 5-(chloromethyl)-4-nitroisoxazole
Product:
substituted (1S,3R)-3-(4-nitroisoxazol-5-yl)-2'-oxospiro[cyclopropane-1,3'-indoline]-2,2-dicarboxylate ester
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylurea
Cas No:
957770-67-1
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2