Hydrogenation, ethyl (Z)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)acrylate, trichlorosilane, ethyl (S)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)propanoate, N-[(8α,9R)-6′-methoxycinchonan-9-yl]-2-pyridinecarboxamide, Quinine DerivativeHydrogenation Isoxazoline cyclization, (R,E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide, hydroxylamine, Optically Enriched Isoxazolines, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization Mannich reaction, 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine, malonates, aldehydes, 2-(((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich Nazarov cyclization, methyl 2-diazo-2-phenylacetate, (E)-4-methyl-1-phenylhex-4-en-1-yn-3-ol, (S)-5-hydroxy-2,3-dimethyl-5-phenyl-4-((R)-2-phenylvinylidene)cyclopent-2-en-1-one, N,N′-bis[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivatveCyclization, Further Cyclizations, Nazarov cyclization Lactonization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, formaldehyde, tetrahydropyranone spirooxindole, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivatveLactonization, Spirocyclization Aza-Henry (Nitro-Mannich), diethyl 2-fluoromalonate, (E)-(2-nitrovinyl)benzene, 4-bromobenzaldehyde, ammonium acetate, ethyl (3S,4S,5S,6R)-6-(4-bromophenyl)-3-fluoro-5-nitro-2-oxo-4-phenylpiperidine-3-carboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Spirocyclization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, 4-fluorobenzaldehyde, ammonium acetate, diethyl (2’R,3R,4’R,5’R)-2′-(4-fluorophenyl)-1-methyl-2,6′-dioxospiro[indoline-3,3′-piperidine]-4′,5′-dicarboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeSpirocyclization Cyclization, (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one, nitromethane, (3R,5R)-4-(nitromethyl)-3,5-diphenylcyclohexan-1-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCyclization, Cycloaddition Addition, dimethyl (E)-but-2-enoylphosphonate, 2-(2-bromophenyl)-4-isopropyloxazol-5(4H)-one, methanol, methyl (R)-3-((R)-2-(2-bromophenyl)-4-isopropyl-5-oxo-2,5-dihydrooxazol-2-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAddition Fluorination, protected piperidin-4-one, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, cis-3-fluoropiperidin-4-ol, trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Fluorination, Fluorination« Older EntriesNext Entries »
Hydrogenation, ethyl (Z)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)acrylate, trichlorosilane, ethyl (S)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)propanoate, N-[(8α,9R)-6′-methoxycinchonan-9-yl]-2-pyridinecarboxamide, Quinine DerivativeHydrogenation
Isoxazoline cyclization, (R,E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide, hydroxylamine, Optically Enriched Isoxazolines, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization
Mannich reaction, 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine, malonates, aldehydes, 2-(((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich
Nazarov cyclization, methyl 2-diazo-2-phenylacetate, (E)-4-methyl-1-phenylhex-4-en-1-yn-3-ol, (S)-5-hydroxy-2,3-dimethyl-5-phenyl-4-((R)-2-phenylvinylidene)cyclopent-2-en-1-one, N,N′-bis[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivatveCyclization, Further Cyclizations, Nazarov cyclization
Lactonization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, formaldehyde, tetrahydropyranone spirooxindole, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivatveLactonization, Spirocyclization
Aza-Henry (Nitro-Mannich), diethyl 2-fluoromalonate, (E)-(2-nitrovinyl)benzene, 4-bromobenzaldehyde, ammonium acetate, ethyl (3S,4S,5S,6R)-6-(4-bromophenyl)-3-fluoro-5-nitro-2-oxo-4-phenylpiperidine-3-carboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Spirocyclization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, 4-fluorobenzaldehyde, ammonium acetate, diethyl (2’R,3R,4’R,5’R)-2′-(4-fluorophenyl)-1-methyl-2,6′-dioxospiro[indoline-3,3′-piperidine]-4′,5′-dicarboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeSpirocyclization
Cyclization, (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one, nitromethane, (3R,5R)-4-(nitromethyl)-3,5-diphenylcyclohexan-1-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCyclization, Cycloaddition
Addition, dimethyl (E)-but-2-enoylphosphonate, 2-(2-bromophenyl)-4-isopropyloxazol-5(4H)-one, methanol, methyl (R)-3-((R)-2-(2-bromophenyl)-4-isopropyl-5-oxo-2,5-dihydrooxazol-2-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAddition
Fluorination, protected piperidin-4-one, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, cis-3-fluoropiperidin-4-ol, trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Fluorination, Fluorination
