Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines.

DOI Number:

10.1021/ol502123z

Reaction Category:

Educt:

substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines

Product:

trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives

Catalyst:

3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1622403-02-4

Cas No:

130-95-0