Michael addition, Spirocyclization, tert-butyl 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (vinylselenonyl)benzene, (S)-5′,6′-dimethoxy-4,5-dihydro-2H-spiro[furan-3,2′-indene]-1′,2(3’H)-dione, (8α,9R)-9-(1-phenanthrenyloxy)-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Lactonization, Michael, Michael Addition, Spirocyclization vinylogous α-ketol rearrangement, substituted 3-(1-hydroxycyclobutyl)cyclohex-2-en-1-one, substituted (S)-spiro[4.5]decane-1,7-dione, (8α,9S)-9-amino-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Spirocyclization vinylogous Mannich reaction, tert-butyl ((3-chlorophenyl)(phenylsulfonyl)methyl)carbamate, 2-(thiochroman-4-ylidene)malononitrile, tert-butyl ((S)-(3-chlorophenyl)((S)-4-(dicyanomethylene)thiochroman-3-yl)methyl)carbamate, (8α,9R)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonidine DerivativeMannich, Mannich Henry reaction, aldehydes, nitromethane, 1-substituted (R)-2-nitroethan-1-ol, 9-([2,2′-bipyridin]-6-yloxy)-6′-methoxy-cinchonan, Quinine DerivativeAldol, Henry, Henry, Nitroaldol Spirocyclization, substituted (E)-4-ethylideneisoxazol-5(4H)-one, substituted 2-cyanoacetate, substituted (3S,4S,5S)-6-oxo-7-oxa-1,8-diazaspiro[4.4]non-8-ene-3-carboxylate, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Spirocyclization Asymmetric desymmetrization, 2,6-disubstituted 4,6-dichloro-5-phenylpyrimidine, benzenethiol, 2,6 disubstituted (r)-4-chloro-5-phenyl-6-(phenylthio)pyrimidine, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAtropisomer synthesis, Desymmetrization Mannich reaction, benzyl ((4-methoxyphenyl)(tosyl)methyl)carbamate, bis(4-methoxyphenyl) malonate, bis(4-methoxyphenyl) (S)-2-((((benzyloxy)carbonyl)amino)(4-methoxyphenyl)methyl)malonate, 9-hydroxy-6′-methoxy-1-[[2-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Quinine DerivativeMannich, Mannich Aza-Henry, Nitro-Mannich, substituted tert-butyl (tosylmethyl)carbamate, primary nitroalkanes, 1,2-substituted tert-butyl ((1R,2S)-2-nitroethyl)carbamate, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Cyanation of unsaturated ketones, tert-butyl (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzoate, 2-hydroxy-2-methylpropanenitrile, cyanopotassium, tert-butyl (R)-4-(3-cyano-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutanoyl)-2-methylbenzoate, 9-hydroxy-6′-methoxy-1-[(2,3,4,5,6-pentafluorophenyl)methyl]-cinchonanium bromide, Quinine DerivativeCyanation Michael addition, 2,3-substituted 3-oxopropanoate, 1-substituted ethene, 2,2,3-tritrisubstituted-(R)-3-oxopropanoate, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinidine DerivativeMichael, Michael Addition, Vinylogous Michael Addition« Older EntriesNext Entries »
Michael addition, Spirocyclization, tert-butyl 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (vinylselenonyl)benzene, (S)-5′,6′-dimethoxy-4,5-dihydro-2H-spiro[furan-3,2′-indene]-1′,2(3’H)-dione, (8α,9R)-9-(1-phenanthrenyloxy)-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Lactonization, Michael, Michael Addition, Spirocyclization
vinylogous α-ketol rearrangement, substituted 3-(1-hydroxycyclobutyl)cyclohex-2-en-1-one, substituted (S)-spiro[4.5]decane-1,7-dione, (8α,9S)-9-amino-Cinchonan-6′-ol, Cupreine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Spirocyclization
vinylogous Mannich reaction, tert-butyl ((3-chlorophenyl)(phenylsulfonyl)methyl)carbamate, 2-(thiochroman-4-ylidene)malononitrile, tert-butyl ((S)-(3-chlorophenyl)((S)-4-(dicyanomethylene)thiochroman-3-yl)methyl)carbamate, (8α,9R)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonidine DerivativeMannich, Mannich
Henry reaction, aldehydes, nitromethane, 1-substituted (R)-2-nitroethan-1-ol, 9-([2,2′-bipyridin]-6-yloxy)-6′-methoxy-cinchonan, Quinine DerivativeAldol, Henry, Henry, Nitroaldol
Spirocyclization, substituted (E)-4-ethylideneisoxazol-5(4H)-one, substituted 2-cyanoacetate, substituted (3S,4S,5S)-6-oxo-7-oxa-1,8-diazaspiro[4.4]non-8-ene-3-carboxylate, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Spirocyclization
Asymmetric desymmetrization, 2,6-disubstituted 4,6-dichloro-5-phenylpyrimidine, benzenethiol, 2,6 disubstituted (r)-4-chloro-5-phenyl-6-(phenylthio)pyrimidine, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAtropisomer synthesis, Desymmetrization
Mannich reaction, benzyl ((4-methoxyphenyl)(tosyl)methyl)carbamate, bis(4-methoxyphenyl) malonate, bis(4-methoxyphenyl) (S)-2-((((benzyloxy)carbonyl)amino)(4-methoxyphenyl)methyl)malonate, 9-hydroxy-6′-methoxy-1-[[2-(trifluoromethyl)phenyl]methyl]-cinchonanium bromide, Quinine DerivativeMannich, Mannich
Aza-Henry, Nitro-Mannich, substituted tert-butyl (tosylmethyl)carbamate, primary nitroalkanes, 1,2-substituted tert-butyl ((1R,2S)-2-nitroethyl)carbamate, 9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Cyanation of unsaturated ketones, tert-butyl (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzoate, 2-hydroxy-2-methylpropanenitrile, cyanopotassium, tert-butyl (R)-4-(3-cyano-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutanoyl)-2-methylbenzoate, 9-hydroxy-6′-methoxy-1-[(2,3,4,5,6-pentafluorophenyl)methyl]-cinchonanium bromide, Quinine DerivativeCyanation
Michael addition, 2,3-substituted 3-oxopropanoate, 1-substituted ethene, 2,2,3-tritrisubstituted-(R)-3-oxopropanoate, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinidine DerivativeMichael, Michael Addition, Vinylogous Michael Addition
