Alpha-Chlorination, 2-phenylacetyl chloride, 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dien-1-one, perchlorophenyl (R)-2-chloro-2-phenylacetate, 6′-methoxy-(9S)-cinchonan-9-ol-9-benzoate, Quinidine DerivativeChlorination Michael Addition, substituted aminoacetonitrile, (E)-but-2-enal, α-aminonitriles, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′,4,4′,5,5′-hexamethoxy[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeMichael, Michael Addition Alkylation, N-acyl sulfenamides, benzyl bromide, sulfilimines, (9S)-9-hydroxy-1-(phenylmethyl)-Cinchonanium chloride, Cinchonine DerivativeAlkylation, S-Alkylation Spirocyclization, indene-based dienes, 3-phenylisoxazol-5(4H)-one, spirodihydrofluorenes, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeSpirocyclization Barbier Reaction, methyl 2,2-dimethyl-3-oxopropanoate, allyl bromide, methyl (S)-3-hydroxy-2,2-dimethylhex-5-enoate, indium, Cinchonine BaseBarbier Reaction, Further reactions Cyclization, 2-aryl acrylic acid, acrylates, butenolides, rhodium catalyst, Cinchonine Base[4+2] Annulation, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition Spirocyclization, 3-isothiocyanato oxindoles, α-ketophosphonates, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization Friedel-Crafts Alkylation, 3‐trifluoroethylidene oxindoles, naphthols, dihydrocoumarins, 3-[[(3,5-dimethoxyphenyl)methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation, Lactonization Aza-Friedel-Crafts Alkylation, acenaphthenequinoneimines, naphthols, hemiketals, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAza-Friedel-Crafts, Friedel-Crafts Cyclization, substituted (E)-4-(5H-pyrrolo[3,2-d]pyrimidin-7-yl)but-3-en-1-amine, N-iodosuccinimide, 2-heteroaryl pyrrolidines, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCyclization, Cyclization, Further Cyclizations, Iodination« Older Entries
Alpha-Chlorination, 2-phenylacetyl chloride, 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dien-1-one, perchlorophenyl (R)-2-chloro-2-phenylacetate, 6′-methoxy-(9S)-cinchonan-9-ol-9-benzoate, Quinidine DerivativeChlorination
Michael Addition, substituted aminoacetonitrile, (E)-but-2-enal, α-aminonitriles, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′,4,4′,5,5′-hexamethoxy[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium bromide, Cinchonine DerivativeMichael, Michael Addition
Alkylation, N-acyl sulfenamides, benzyl bromide, sulfilimines, (9S)-9-hydroxy-1-(phenylmethyl)-Cinchonanium chloride, Cinchonine DerivativeAlkylation, S-Alkylation
Spirocyclization, indene-based dienes, 3-phenylisoxazol-5(4H)-one, spirodihydrofluorenes, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeSpirocyclization
Barbier Reaction, methyl 2,2-dimethyl-3-oxopropanoate, allyl bromide, methyl (S)-3-hydroxy-2,2-dimethylhex-5-enoate, indium, Cinchonine BaseBarbier Reaction, Further reactions
Cyclization, 2-aryl acrylic acid, acrylates, butenolides, rhodium catalyst, Cinchonine Base[4+2] Annulation, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition
Spirocyclization, 3-isothiocyanato oxindoles, α-ketophosphonates, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization
Friedel-Crafts Alkylation, 3‐trifluoroethylidene oxindoles, naphthols, dihydrocoumarins, 3-[[(3,5-dimethoxyphenyl)methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation, Lactonization
Aza-Friedel-Crafts Alkylation, acenaphthenequinoneimines, naphthols, hemiketals, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAza-Friedel-Crafts, Friedel-Crafts
Cyclization, substituted (E)-4-(5H-pyrrolo[3,2-d]pyrimidin-7-yl)but-3-en-1-amine, N-iodosuccinimide, 2-heteroaryl pyrrolidines, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCyclization, Cyclization, Further Cyclizations, Iodination
