Strecker Reaction, substituted 3-iminoindolin-2-one, trimethylsilyl cyanide, substituted (R)-3-amino-2-oxoindoline-3-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeStrecker Strecker Reaction, substituted 3-iminoindolin-2-one, trimethylsilyl cyanide, substituted (R)-3-amino-2-oxoindoline-3-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeStrecker Strecker Reaction, pyrazolones, trimethylsilyl cyanide, pyrazolone α-aminonitrile derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker Strecker Reaction, thiazole imines, trimethylsilyl cyanide, substituted 2-(benzo[d]thiazol-2-ylamino)acetonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker Alkylation, 2,4-disubstituted oxazol-5(4H)-ones, brominated hydrocarbons, 2,4,4-trisubstituted oxazol-5(4H)-ones, (8α,9R)-(8′′α,9′′R)- 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-Cinchonanium chloride, Cinchonidine DerivativeAlkylation, Alkylation Bromination, substituted bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, N-bromosuccinimide, 6-bromo-6,6a-dibutyl-2-oxohexahydro-2H-3,5-methanocyclopenta[b]furan-7-carboxylic acid, gold-catalyst, 1-(2-bromophenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea, Cinchonidine DerivativeBromination, Lactonization Desymmetrization, (1R,2S)-cyclohexane-1,2-diol, benzenesulfonyl chloride, (1R,2S)-2-hydroxycyclohexyl benzenesulfonate, 1-methylimidazole, 2-(8α,9S)-cinchonan-9-yl-2,3-dihydro-1H-2,1-Benzazaborol-1-ol, Cinchonidine DerivativeDesymmetrization, Further reactions, Sulfonylation Atropisomer Synthesis, (E)-10-((([1,1′-biphenyl]-2-carbonyl)oxy)imino)-4,5-dimethylphenanthren-9(10H)-one, aniline, axially chiral biarylnitriles, (8α,9R)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonidine DerivativeAtropisomer synthesis Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-(8′′α,9′′R)-(8′′′′α,9′′′′R)-1,1′′,1′′′′-[1,3,5-benzenetriyltris(methylene)]tris[9-(2-propenyloxy)-cinchonanium tribromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation Racemic resolution, trichostatic acid, R-trichostatic acid, Cinchonidine BaseRacemic resolution, Resolution« Older Entries
Strecker Reaction, substituted 3-iminoindolin-2-one, trimethylsilyl cyanide, substituted (R)-3-amino-2-oxoindoline-3-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeStrecker
Strecker Reaction, substituted 3-iminoindolin-2-one, trimethylsilyl cyanide, substituted (R)-3-amino-2-oxoindoline-3-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeStrecker
Strecker Reaction, pyrazolones, trimethylsilyl cyanide, pyrazolone α-aminonitrile derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker
Strecker Reaction, thiazole imines, trimethylsilyl cyanide, substituted 2-(benzo[d]thiazol-2-ylamino)acetonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker
Alkylation, 2,4-disubstituted oxazol-5(4H)-ones, brominated hydrocarbons, 2,4,4-trisubstituted oxazol-5(4H)-ones, (8α,9R)-(8′′α,9′′R)- 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-Cinchonanium chloride, Cinchonidine DerivativeAlkylation, Alkylation
Bromination, substituted bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, N-bromosuccinimide, 6-bromo-6,6a-dibutyl-2-oxohexahydro-2H-3,5-methanocyclopenta[b]furan-7-carboxylic acid, gold-catalyst, 1-(2-bromophenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea, Cinchonidine DerivativeBromination, Lactonization
Desymmetrization, (1R,2S)-cyclohexane-1,2-diol, benzenesulfonyl chloride, (1R,2S)-2-hydroxycyclohexyl benzenesulfonate, 1-methylimidazole, 2-(8α,9S)-cinchonan-9-yl-2,3-dihydro-1H-2,1-Benzazaborol-1-ol, Cinchonidine DerivativeDesymmetrization, Further reactions, Sulfonylation
Atropisomer Synthesis, (E)-10-((([1,1′-biphenyl]-2-carbonyl)oxy)imino)-4,5-dimethylphenanthren-9(10H)-one, aniline, axially chiral biarylnitriles, (8α,9R)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonidine DerivativeAtropisomer synthesis
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-(8′′α,9′′R)-(8′′′′α,9′′′′R)-1,1′′,1′′′′-[1,3,5-benzenetriyltris(methylene)]tris[9-(2-propenyloxy)-cinchonanium tribromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation
Racemic resolution, trichostatic acid, R-trichostatic acid, Cinchonidine BaseRacemic resolution, Resolution
