Cross-Coupling, terminal alkenes, terminal alkynes, hetetrocycles, heterocyclic acetylene compounds, copper catalyst, 2-[Bis[3,5-bis(1,1-dimethylethyl)phenyl]phosphino]- N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzamide, Quinine DerivativeCross Coupling Atropisomer Synthesis, 1-phenyl-3-(2-phenyl-1H-indol-1-yl)prop-2-yn-1-one, tert-butyl 2-isocyanoacetate, tert-butyl 4-benzoyl-3-(2-phenyl-1H-indol-1-yl)-1H-pyrrole-2-carboxylate, silver acetate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis Isoxazoline Cyclization, (Z)-4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide, hydroxylamine, (s)-afoxolaner, (8α,9R)-9-hydroxy-6′-methoxy-1-[[3,4,5-tris[(4-methylphenyl)methyl]phenyl]methyl]-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization Isoxazoline Cyclization, (Z)-4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide, hydroxylamine, (s)-afoxolaner, N-(9-Acridinylmethyl)quininium Bromide, Quinine DerivativeCyclization, Isoxazoline cyclization Mannich reaction, Boc-protected phenylmethanimine, pentane-2,4-dione, Boc-protected 3-(amino(phenyl)methyl)pentane-2,4-dione, Cinchonine BaseMannich, Mannich Atropisomer Synthesis, 2-methylquinazolin-4(3H)-one, Boc-protected tert-butyl 2-((4-chlorophenyl)(hydroxy)methyl)acrylate, N‐vinylquinazolinones, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeAtropisomer synthesis Amination, 2-(hydroxy(pyridin-2-yl)methyl)acrylates, quinolinones, N‐vinylquinolinones, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeAllylic Amination, Amination, Further reactions, Substitution Kinetic Resolution, BINOLs, di-tert-butyl dicarbonate, Boc-protected BINOLs, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeAtropisomer synthesis, Kinetic resolution, Resolution Desymmetrization, bisallylic amides, N-chlorophthalimide, substitued 4-vinyl-5,6-dihydro-4H-1,3-oxazine, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeChlorination, Cyclization, Cyclization, Desymmetrization, Further Cyclizations Bromination, substituted styrene, 1-naphthoic acid, N-bromobenzamide, substituted 2-bromo-1-phenylethyl 1-naphthoate, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeBromination« Older Entries
Cross-Coupling, terminal alkenes, terminal alkynes, hetetrocycles, heterocyclic acetylene compounds, copper catalyst, 2-[Bis[3,5-bis(1,1-dimethylethyl)phenyl]phosphino]- N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzamide, Quinine DerivativeCross Coupling
Atropisomer Synthesis, 1-phenyl-3-(2-phenyl-1H-indol-1-yl)prop-2-yn-1-one, tert-butyl 2-isocyanoacetate, tert-butyl 4-benzoyl-3-(2-phenyl-1H-indol-1-yl)-1H-pyrrole-2-carboxylate, silver acetate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis
Isoxazoline Cyclization, (Z)-4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide, hydroxylamine, (s)-afoxolaner, (8α,9R)-9-hydroxy-6′-methoxy-1-[[3,4,5-tris[(4-methylphenyl)methyl]phenyl]methyl]-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization
Isoxazoline Cyclization, (Z)-4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide, hydroxylamine, (s)-afoxolaner, N-(9-Acridinylmethyl)quininium Bromide, Quinine DerivativeCyclization, Isoxazoline cyclization
Mannich reaction, Boc-protected phenylmethanimine, pentane-2,4-dione, Boc-protected 3-(amino(phenyl)methyl)pentane-2,4-dione, Cinchonine BaseMannich, Mannich
Atropisomer Synthesis, 2-methylquinazolin-4(3H)-one, Boc-protected tert-butyl 2-((4-chlorophenyl)(hydroxy)methyl)acrylate, N‐vinylquinazolinones, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeAtropisomer synthesis
Amination, 2-(hydroxy(pyridin-2-yl)methyl)acrylates, quinolinones, N‐vinylquinolinones, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeAllylic Amination, Amination, Further reactions, Substitution
Kinetic Resolution, BINOLs, di-tert-butyl dicarbonate, Boc-protected BINOLs, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeAtropisomer synthesis, Kinetic resolution, Resolution
Desymmetrization, bisallylic amides, N-chlorophthalimide, substitued 4-vinyl-5,6-dihydro-4H-1,3-oxazine, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeChlorination, Cyclization, Cyclization, Desymmetrization, Further Cyclizations
Bromination, substituted styrene, 1-naphthoic acid, N-bromobenzamide, substituted 2-bromo-1-phenylethyl 1-naphthoate, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeBromination
