Strecker Synthesis, dibenzo[b,f][1,4]oxazepines, trimethylsilyl cyanide, substituted (R)-10,11-dihydrodibenzo[b,f][1,4]oxazepine-11-carbonitrile, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeStrecker Mannich reaction, 3-fluorooxindoles, dibenzo[b,f][1,4]oxazepines, tetrasubstituted C–F stereocenters, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(trifluoromethyl)phenyl]-thiourea, Dihydroquinine DerivativeMannich, Mannich Spirocyclization, substituted 1-(2-(3-oxocyclobutyl)phenyl)hept-4-ene-1,6-dione, cyclobutanone fused oxa-spirocycles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction, Spirocyclization Atropisomer Synthesis, 1-(alkynyl)naphthalen-2-ols, cyclopropanols, DABCO-bis(sulfur dioxide), atropisomeric sulfonyls, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeAtropisomer synthesis, Further reactions, Sulfonylation Michael Addition, 2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)ethan-1-one, (E)-1-(2-nitrovinyl)-2-(trifluoromethyl)benzene, (2R,3S)-4-nitro-2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)-3-(2-(trifluoromethyl)phenyl)butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeMichael, Michael Addition Cyclization, aminochalcones, azlactones, 3,4-dihydroquinolinones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Cyclization, seven-membered cyclic N-sulfonylimines, γ-hydroxy-α,β-unsaturated ketones, [5.7]-fused ε-sultam N,O-heterocycles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine Derivative[3+2] Annulation, Cyclization, Further Cyclizations Lactonization, 2-keto succinates, formaldehyde, γ-butyrolactones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxy-2′-phenylcinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Dihydroquinine DerivativeAldol, Aldol, Lactonization Sulfa-Michael Addition, aryl substituted α,β-unsaturated N-acyl pyrazoles, benzenethiol, (R)-3-cyclohexyl-3-(phenylthio)-1-(1H-pyrazol-1-yl)propan-1-one, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Dihydroxylation, (E)-prop-1-en-1-ylbenzene, (1R,2R)-1-phenylpropane-1,2-diol, osmium(VIII) oxide, (8α,9R)-(8′′α,9′′R)-9,9′′-[1,4-Phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeDihydroxylation, Further reactions, Hydroxylation« Older Entries
Strecker Synthesis, dibenzo[b,f][1,4]oxazepines, trimethylsilyl cyanide, substituted (R)-10,11-dihydrodibenzo[b,f][1,4]oxazepine-11-carbonitrile, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeStrecker
Mannich reaction, 3-fluorooxindoles, dibenzo[b,f][1,4]oxazepines, tetrasubstituted C–F stereocenters, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(trifluoromethyl)phenyl]-thiourea, Dihydroquinine DerivativeMannich, Mannich
Spirocyclization, substituted 1-(2-(3-oxocyclobutyl)phenyl)hept-4-ene-1,6-dione, cyclobutanone fused oxa-spirocycles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction, Spirocyclization
Atropisomer Synthesis, 1-(alkynyl)naphthalen-2-ols, cyclopropanols, DABCO-bis(sulfur dioxide), atropisomeric sulfonyls, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeAtropisomer synthesis, Further reactions, Sulfonylation
Michael Addition, 2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)ethan-1-one, (E)-1-(2-nitrovinyl)-2-(trifluoromethyl)benzene, (2R,3S)-4-nitro-2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)-3-(2-(trifluoromethyl)phenyl)butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeMichael, Michael Addition
Cyclization, aminochalcones, azlactones, 3,4-dihydroquinolinones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Cyclization, seven-membered cyclic N-sulfonylimines, γ-hydroxy-α,β-unsaturated ketones, [5.7]-fused ε-sultam N,O-heterocycles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine Derivative[3+2] Annulation, Cyclization, Further Cyclizations
Lactonization, 2-keto succinates, formaldehyde, γ-butyrolactones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxy-2′-phenylcinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Dihydroquinine DerivativeAldol, Aldol, Lactonization
Sulfa-Michael Addition, aryl substituted α,β-unsaturated N-acyl pyrazoles, benzenethiol, (R)-3-cyclohexyl-3-(phenylthio)-1-(1H-pyrazol-1-yl)propan-1-one, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Dihydroxylation, (E)-prop-1-en-1-ylbenzene, (1R,2R)-1-phenylpropane-1,2-diol, osmium(VIII) oxide, (8α,9R)-(8′′α,9′′R)-9,9′′-[1,4-Phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeDihydroxylation, Further reactions, Hydroxylation
