Cyclization, 5-benzyl-5-(2-hydroxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione, (S)-3-benzylchroman-2-one, (8α,9R)-9-(diphenylmethoxy)-cinchonan-6′-ol, Dihydrocupreine DerivativeCyclization, Cyclization, Further Cyclizations Epimerization, dimethyl (1R,2S,3R,4S,5R,6S)-4,5-dihydroxy-3,6-dimethylcyclohexane-1,2-dicarboxylate, dimethyl (1R,2S,3R,4R,5R,6S)-4,5-dihydroxy-3,6-dimethylcyclohexane-1,2-dicarboxylate, N-[(9S)-10,11-dihydrocinchonan-9-yl]-carbamic acid 1,1-dimethylethyl ester, Dihydrocinchonidine DerivativeDesymmetrization, Isomerization Ring Opening, 4-isopropyl-2-phenyloxazol-5(4H)-one, allyl alcohol, allyl benzoylvalinate, N,N′-bis[(8α,9S)-10,11-dihydrocinchonan-9-yl]-thiourea, Dihydrocinchonidine DerivativeFurther reactions, Ring opening Alpha-Alkylation, tert-butyl 2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, 1-(bromomethyl)-4-fluorobenzene, tert-butyl (R)-4-(4-fluorobenzyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)-1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, substituted 3-(bromomethyl)-1H-indole, substituted tert-butyl (S)-2-((diphenylmethylene)amino)-3-(1H-indol-3-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromo-2-methylprop-1-ene, tert-butyl (S)-2-((diphenylmethylene)amino)-4-methylpent-4-enoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 10-(bromomethyl)-2,3,6-trimethoxyphenanthrene, tert-butyl (S)-2-((diphenylmethylene)amino)-3-(3,6,7-trimethoxyphenanthren-9-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 2-(benzyloxy)-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one, tert-butyl 3-(bromomethyl)-1H-indole-1-carboxylate, tert-butyl (S)-3-(2-(benzyloxy)-3-(1-methyl-1H-imidazol-2-yl)-3-oxopropyl)-1H-indole-1-carboxylate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation« Older Entries
Cyclization, 5-benzyl-5-(2-hydroxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione, (S)-3-benzylchroman-2-one, (8α,9R)-9-(diphenylmethoxy)-cinchonan-6′-ol, Dihydrocupreine DerivativeCyclization, Cyclization, Further Cyclizations
Epimerization, dimethyl (1R,2S,3R,4S,5R,6S)-4,5-dihydroxy-3,6-dimethylcyclohexane-1,2-dicarboxylate, dimethyl (1R,2S,3R,4R,5R,6S)-4,5-dihydroxy-3,6-dimethylcyclohexane-1,2-dicarboxylate, N-[(9S)-10,11-dihydrocinchonan-9-yl]-carbamic acid 1,1-dimethylethyl ester, Dihydrocinchonidine DerivativeDesymmetrization, Isomerization
Ring Opening, 4-isopropyl-2-phenyloxazol-5(4H)-one, allyl alcohol, allyl benzoylvalinate, N,N′-bis[(8α,9S)-10,11-dihydrocinchonan-9-yl]-thiourea, Dihydrocinchonidine DerivativeFurther reactions, Ring opening
Alpha-Alkylation, tert-butyl 2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, 1-(bromomethyl)-4-fluorobenzene, tert-butyl (R)-4-(4-fluorobenzyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)-1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, substituted 3-(bromomethyl)-1H-indole, substituted tert-butyl (S)-2-((diphenylmethylene)amino)-3-(1H-indol-3-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromo-2-methylprop-1-ene, tert-butyl (S)-2-((diphenylmethylene)amino)-4-methylpent-4-enoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 10-(bromomethyl)-2,3,6-trimethoxyphenanthrene, tert-butyl (S)-2-((diphenylmethylene)amino)-3-(3,6,7-trimethoxyphenanthren-9-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 2-(benzyloxy)-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one, tert-butyl 3-(bromomethyl)-1H-indole-1-carboxylate, tert-butyl (S)-3-(2-(benzyloxy)-3-(1-methyl-1H-imidazol-2-yl)-3-oxopropyl)-1H-indole-1-carboxylate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
