6´-Aminocinchonidine (CAS-No. 2143936-34-7) is a new member of the Cinchona Alkaloid family. The additional primary...
Buchler Glossary
A Knoevenagel Reaction is a condensation between an aldehyde or a ketone with an active hydrogen compound in the presence of a basic catalyst to yield α,β-unsaturated compounds. In 2011, Benjamin List (Nobel Prize 2021 in Chemistry) and co-workers published the first asymmetric example of a Knoevenagel condensation that proceeds through a dynamic kinetic resolution of α-branched aldehydes using a 9-Epiamino Cinchona alkaloid catalyst. 9-Epiamino Cinchona alkaloids, and their derivatives are excellent organocatalysts in a huge variety of asymmetric synthesis.
Knoevenagel reaction examples catalyzed by cinchona alkaloid derivatives can be found in our free of charge Chiral Catalyst Search Data Base.
Example from Literature
The Catalytic Asymmetric Knoevenagel Condensation. (List et al.; Angew. Chem.Int. Ed. 2011, 50(7), 1707-1710.)
Further Articles:
6´-Aminodihydrocinchonidine (CAS-No. 107781-90-8)
6´-Aminodihydrocinchonidine Base (CAS-No. 107781-90-8) is a cinchona alkaloid closely related to 6´-Aminocinchonidine....
6´-Aminodihydrocinchonine (CAS-No. 911708-35-5)
6´-Aminodihydrocinchonine Base (CAS-No. 911708-35-5) is a cinchona alkaloid closely related to 6´-Aminocinchonine....
Alkynylation
Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...
Allylsilylations
Allylsilylations are performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...
Aminohydroxylation
The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...