Alkylation, methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, ethyl 2,2-difluoro-2-iodoacetate, methyl (R)-2-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, 1-[2-([1,1′-biphenyl]-2-ylamino)-2-oxoethyl]- 9-hydroxy-(8α,9R)-Cinchonanium bromide, Cinchonidine DerivativeAlkylation, Alkylation Alkylation, tert-butyl (1-benzyl-2-oxoindolin-3-yl)(2-chloroethyl)carbamate, tert-butyl (S)-1′-benzyl-2′-oxospiro[azetidine-2,3′-indoline]-1-carboxylate, (1S,2S,4S,5R)-2-((R)-hydroxy(quinolin-4-yl)methyl)-1-(4-(pentafluoro-l6-sulfaneyl)benzyl)-5-vinylquinuclidin-1-ium bromide, Cinchonidine DerivativeAlkylation, Alkylation, Spirocyclization Arylation, 4-(3-methoxybenzyl)-3-methylisoxazol-5(4H)-one, N,N’-((1E,2Z)-cyclohexa-3,5-diene-1,2-diylidene)dibenzamide, (R)-N,N’-(4-(4-(3-methoxybenzyl)-3-methyl-5-oxo-4,5-dihydroisoxazol-4-yl)-1,2-phenylene)dibenzamide, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeArylation, Further reactions Vinylogous Michael Addition, tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, 5-(chloromethyl)-3-methyl-4-nitroisoxazole, tert-butyl (1R,3S)-2,2-dimethyl-3-(3-methyl-4-nitroisoxazol-5-yl)-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylurea, Cinchonidine DerivativeCyclopropanation, Michael Addition, Vinylogous Michael Addition Racemic resolution, 4-cyano-4-(4-nitrophenyl)hexanoic acid, (R)-4-cyano-4-(4-nitrophenyl)hexanoic acid, Cinchonidine BaseRacemic resolution, Resolution Michael Addition, tert-butyl 3-fluoro-2-oxoindoline-1-carboxylates, 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-ones, tert-butyl (R)-3-((S)-(3,5-di-tert-butyl-4-hydroxyphenyl)(phenyl)methyl)-3-fluoro-2-oxoindoline-1-carboxylates, O-Allyl-1-(anthracen-9-ylmethyl)-cinchonidinium bromide, Cinchonidine DerivativeMichael, Michael Addition Michael Addition, cyclic 1, 3‐dicarbonyl compounds, α,β‐unsaturated ketones, warfarin anticoagulant, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition Oxa-Michael, substituted (2E)-3-(2-hydroxyphenyl)prop-2-enon, nitroalkenes, substituted chromans, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Michael Addition, Oxa-Michael Addition Thioalkylation, substituted 2-phenyl-2,3-dihydronaphthalene-1,4-dione, substituted benzenethiol, substituted 2-phenyl-3-(phenylthio)-2,3-dihydronaphthalene-1,4-dione, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-2,4,6-trimethyl-benzamide, Quinine DerivativeAtropisomer synthesis Michael Addition, substituted ((nitromethyl)sulfonyl)benzene, α,β‐unsaturated ketones, α-nitro-δ-ketosulfones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Alkylation, methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, ethyl 2,2-difluoro-2-iodoacetate, methyl (R)-2-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, 1-[2-([1,1′-biphenyl]-2-ylamino)-2-oxoethyl]- 9-hydroxy-(8α,9R)-Cinchonanium bromide, Cinchonidine DerivativeAlkylation, Alkylation
Alkylation, tert-butyl (1-benzyl-2-oxoindolin-3-yl)(2-chloroethyl)carbamate, tert-butyl (S)-1′-benzyl-2′-oxospiro[azetidine-2,3′-indoline]-1-carboxylate, (1S,2S,4S,5R)-2-((R)-hydroxy(quinolin-4-yl)methyl)-1-(4-(pentafluoro-l6-sulfaneyl)benzyl)-5-vinylquinuclidin-1-ium bromide, Cinchonidine DerivativeAlkylation, Alkylation, Spirocyclization
Arylation, 4-(3-methoxybenzyl)-3-methylisoxazol-5(4H)-one, N,N’-((1E,2Z)-cyclohexa-3,5-diene-1,2-diylidene)dibenzamide, (R)-N,N’-(4-(4-(3-methoxybenzyl)-3-methyl-5-oxo-4,5-dihydroisoxazol-4-yl)-1,2-phenylene)dibenzamide, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeArylation, Further reactions
Vinylogous Michael Addition, tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, 5-(chloromethyl)-3-methyl-4-nitroisoxazole, tert-butyl (1R,3S)-2,2-dimethyl-3-(3-methyl-4-nitroisoxazol-5-yl)-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylurea, Cinchonidine DerivativeCyclopropanation, Michael Addition, Vinylogous Michael Addition
Racemic resolution, 4-cyano-4-(4-nitrophenyl)hexanoic acid, (R)-4-cyano-4-(4-nitrophenyl)hexanoic acid, Cinchonidine BaseRacemic resolution, Resolution
Michael Addition, tert-butyl 3-fluoro-2-oxoindoline-1-carboxylates, 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-ones, tert-butyl (R)-3-((S)-(3,5-di-tert-butyl-4-hydroxyphenyl)(phenyl)methyl)-3-fluoro-2-oxoindoline-1-carboxylates, O-Allyl-1-(anthracen-9-ylmethyl)-cinchonidinium bromide, Cinchonidine DerivativeMichael, Michael Addition
Michael Addition, cyclic 1, 3‐dicarbonyl compounds, α,β‐unsaturated ketones, warfarin anticoagulant, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition
Oxa-Michael, substituted (2E)-3-(2-hydroxyphenyl)prop-2-enon, nitroalkenes, substituted chromans, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Michael Addition, Oxa-Michael Addition
Thioalkylation, substituted 2-phenyl-2,3-dihydronaphthalene-1,4-dione, substituted benzenethiol, substituted 2-phenyl-3-(phenylthio)-2,3-dihydronaphthalene-1,4-dione, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-2,4,6-trimethyl-benzamide, Quinine DerivativeAtropisomer synthesis
Michael Addition, substituted ((nitromethyl)sulfonyl)benzene, α,β‐unsaturated ketones, α-nitro-δ-ketosulfones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
