Desymmetrization, geminal diols, substituted tetrahydropyran-2-ol, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Desymmetrization, Further Cyclizations, Intramolecular cyclization Sulfa-Michael Addition, arylmethylidenemalonates, thioacetic acid, diethyl (R)-2-((acetylthio)(aryl)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Cyclization, substituted diethyl (E)-2-((2-hydroxybenzylidene)amino)malonate, substituted oxazol-5(4H)-one, polysubstituted chromeno[4,3-b]pyrrolidines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Further Cyclizations Mannich reaction, imines, malonates, substituted dimethyl 2-(aminomethyl)malonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Michael Addition, oxindoles, nitroolefins, 2,2-disubstituted oxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition Spirocyclization, barbiturate‐based olefins, 3‐isothiocyanato oxindoles, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization Spirocyclization, isatin-derived β,γ-unsaturated α-ketoesters, substituted 2-hydroxy-1,4-naphthoquinone, spirocycles, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization Michael Addition, ethyl (Z)-3-nitro-2-(p-tolyl)acrylate, 5-isobutylfuran-2(3H)-one, ethyl (R)-2-((R)-2-isobutyl-5-oxo-2,5-dihydrofuran-2-yl)-3-nitro-2-(p-tolyl)propanoate, (8α,9S)-9-[[2,4,6-Tris(1-methylethyl)phenyl]methoxy]cinchonan-6′-ol, Cupreine DerivativeMichael, Michael Addition Michael Addition, α-aryl-α-isocyanoacetates, (Ethenylselenonyl)benzene, α,α-disubstituted α-amino acids, (8α,9R)-9-Butoxycinchonan-6′-ol, Cupreine DerivativeMichael, Michael Addition Spirocyclization, isatin-derived β,γ-unsaturated α-ketoesters, substituted 3-hydroxy-4H-chromen-4-one, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization« Older EntriesNext Entries »
Desymmetrization, geminal diols, substituted tetrahydropyran-2-ol, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Desymmetrization, Further Cyclizations, Intramolecular cyclization
Sulfa-Michael Addition, arylmethylidenemalonates, thioacetic acid, diethyl (R)-2-((acetylthio)(aryl)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Cyclization, substituted diethyl (E)-2-((2-hydroxybenzylidene)amino)malonate, substituted oxazol-5(4H)-one, polysubstituted chromeno[4,3-b]pyrrolidines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Further Cyclizations
Mannich reaction, imines, malonates, substituted dimethyl 2-(aminomethyl)malonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Michael Addition, oxindoles, nitroolefins, 2,2-disubstituted oxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition
Spirocyclization, barbiturate‐based olefins, 3‐isothiocyanato oxindoles, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization
Spirocyclization, isatin-derived β,γ-unsaturated α-ketoesters, substituted 2-hydroxy-1,4-naphthoquinone, spirocycles, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization
Michael Addition, ethyl (Z)-3-nitro-2-(p-tolyl)acrylate, 5-isobutylfuran-2(3H)-one, ethyl (R)-2-((R)-2-isobutyl-5-oxo-2,5-dihydrofuran-2-yl)-3-nitro-2-(p-tolyl)propanoate, (8α,9S)-9-[[2,4,6-Tris(1-methylethyl)phenyl]methoxy]cinchonan-6′-ol, Cupreine DerivativeMichael, Michael Addition
Michael Addition, α-aryl-α-isocyanoacetates, (Ethenylselenonyl)benzene, α,α-disubstituted α-amino acids, (8α,9R)-9-Butoxycinchonan-6′-ol, Cupreine DerivativeMichael, Michael Addition
Spirocyclization, isatin-derived β,γ-unsaturated α-ketoesters, substituted 3-hydroxy-4H-chromen-4-one, spirocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization
