alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, alkyl halides, alpha-alkylated tert-butyl 2-((diphenylmethylene)amino)acetate, (9S)-1-(1H-benzotriazol-1-ylmethyl)-9-hydroxy-Cinchonanium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation Addition of enamies to trifluoropyruvate, enamine, trifluoropyruvate, small heterocyclic molecules with a quaternary trifluoromethylated carbon center, Cinchonine BaseAddition Aldol reaction, alkyl azalactones, aliphatic aldehydes, aldol adduct, 4-((S)-((6-chloro-2,5-diphenylpyrimidin-4-yl)oxy)((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)methyl)quinolin-6-ol, Dihydrocupreidine DerivativeAldol, Aldol Mannich reaction, 4-hydroxy-2H-chromen-2-one, (E)-N-(2-bromobenzylidene)-4-methylbenzenesulfonamide, (R)-N-((2-bromophenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-4-methylbenzenesulfonamide, Cupreine BaseMannich, Mannich Hydroxyalkylation of indole with ethyl 3,3,3-trifluoro-2-oxopropanoate, ethyl (S)-3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate, Cinchonidine BaseFurther reactions, Hydroxyalkylation Aza-Henry (Nitro-Mannich), 6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, (2-nitroethyl)cyclopropane, (R)-6-chloro-4-((S)-2-cyclopropyl-1-nitroethyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one, 1-(4-((R)-(benzyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea, 6´-Aminocinchonidine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Asymmetric intramolecular annulation, 1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one, (S)-1′-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one, (1S,2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methoxyquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeSpirocyclization 3+2 cycloaddition, 6-bromo-3-(4-methoxybenzoyl)-2H-chromen-2-one, dimethyl (E)-2-((5-bromo-2-hydroxybenzylidene)amino)malonate, dimethyl (3R,3aR,9bR)-8-bromo-3-(5-bromo-2-((4-methoxybenzoyl)oxy)phenyl)-4-oxo-2,3,3a,9b-tetrahydrochromeno[3,4-c]pyrrole-1,1(4H)-dicarboxylate, Quinidine Base[3+2]-Cycloaddition, Cyclization, Cycloaddition 2+2 Cycloaddition, 2-methylprop-1-en-1-one, 2,2,2-trichloroacetaldehyde, (S)-4-(trichloromethyl)oxetan-2-one, Quinidine Base[2+2]-Cycloaddition, Cycloaddition, Lactonization Michael Addition, ethyl 2-nitropropanoate, (E)-(2-nitrovinyl)benzene, ethyl (2S,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate, ethyl (2R,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, alkyl halides, alpha-alkylated tert-butyl 2-((diphenylmethylene)amino)acetate, (9S)-1-(1H-benzotriazol-1-ylmethyl)-9-hydroxy-Cinchonanium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation
Addition of enamies to trifluoropyruvate, enamine, trifluoropyruvate, small heterocyclic molecules with a quaternary trifluoromethylated carbon center, Cinchonine BaseAddition
Aldol reaction, alkyl azalactones, aliphatic aldehydes, aldol adduct, 4-((S)-((6-chloro-2,5-diphenylpyrimidin-4-yl)oxy)((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)methyl)quinolin-6-ol, Dihydrocupreidine DerivativeAldol, Aldol
Mannich reaction, 4-hydroxy-2H-chromen-2-one, (E)-N-(2-bromobenzylidene)-4-methylbenzenesulfonamide, (R)-N-((2-bromophenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-4-methylbenzenesulfonamide, Cupreine BaseMannich, Mannich
Hydroxyalkylation of indole with ethyl 3,3,3-trifluoro-2-oxopropanoate, ethyl (S)-3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate, Cinchonidine BaseFurther reactions, Hydroxyalkylation
Aza-Henry (Nitro-Mannich), 6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, (2-nitroethyl)cyclopropane, (R)-6-chloro-4-((S)-2-cyclopropyl-1-nitroethyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one, 1-(4-((R)-(benzyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea, 6´-Aminocinchonidine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Asymmetric intramolecular annulation, 1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one, (S)-1′-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one, (1S,2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methoxyquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeSpirocyclization
3+2 cycloaddition, 6-bromo-3-(4-methoxybenzoyl)-2H-chromen-2-one, dimethyl (E)-2-((5-bromo-2-hydroxybenzylidene)amino)malonate, dimethyl (3R,3aR,9bR)-8-bromo-3-(5-bromo-2-((4-methoxybenzoyl)oxy)phenyl)-4-oxo-2,3,3a,9b-tetrahydrochromeno[3,4-c]pyrrole-1,1(4H)-dicarboxylate, Quinidine Base[3+2]-Cycloaddition, Cyclization, Cycloaddition
2+2 Cycloaddition, 2-methylprop-1-en-1-one, 2,2,2-trichloroacetaldehyde, (S)-4-(trichloromethyl)oxetan-2-one, Quinidine Base[2+2]-Cycloaddition, Cycloaddition, Lactonization
Michael Addition, ethyl 2-nitropropanoate, (E)-(2-nitrovinyl)benzene, ethyl (2S,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate, ethyl (2R,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition
