Bifunctional squaramide catalysts with the same absolute chirality for the diastereodivergent access to densely functionalised cyclohexanes through enantioselective domino reactions. Synthesis and mechanistic studies.

DOI Number:

10.1002/adsc.201400502

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

ethyl 2-nitropropanoate, (E)-(2-nitrovinyl)benzene

Product:

ethyl (2S,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate, ethyl (2R,3R)-2-methyl-2,4-dinitro-3-phenylbutanoate

Catalyst:

3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1362169-08-1

Cas No:

56-54-2