Michael Addition, maleimides, aldehydes, 2-(1-substituted-2,5-dioxopyrrolidin-3-yl)-2-substituted-acetaldehyde, (9R)-Cinchonan-9-amine, triphenylphosphine, Cinchonine DerivativeMichael, Michael Addition Michael Addition, unprotected 3-substituted oxindoles, beta-substituted nitroalkenes, 5-substituted-3-substituted-3-(1-nitroalkan-2-yl)indolin-2-one, Diethyl N-(9R)-cinchonan-9-ylphosphoramidate, Cinchonine DerivativeMichael, Michael Addition Trifluoromethylation of aryl ketones, aryl ketones, trimethyl(trifluoromethyl)silane, trifluoromethyl-substituted aryl alcohols, (1S,1’S,2R,2’R,4S,4’S,5R,5’R)-1,1′-(1,3-phenylenebis(methylene))bis(2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium) bromide, tetramethylammonium fluoride, Cinchonine DerivativeTrifluoromethylation Desymmetrization of aziridines with phosphites, (7-azabicyclo[4.1.0]heptan-7-yl)(pyridin-2-yl)methanone (aziridine), diphenyl phosphonate (phosphite), diphenyl ((1R,2R)-2-(picolinamido)cyclohexyl)phosphonate, N-(9R)-Cinchonan-9-yl-2-pyridinecarboxamide, Cinchonine DerivativeDesymmetrization Intramolecular aza-Michael, N-(2-((4′-fluoro-4-oxo-[1,1′-biphenyl]-1(4H)-yl)oxy)ethyl)-4-methylbenzenesulfonamide (cyclohexadienones), (4S,4aS,8aS)-8a-(4-fluorophenyl)-4-tosyl-3,4,4a,8a-tetrahydro-2H-4lambda4-benzo[b][1,4]oxazin-6(5H)-one (morpholine derivative), 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea, Cinchonine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition Alkylation, alpha-monosubstituted malonic diesters, alkyl dihalides, alpha,alpha-disubstituted malonic diesters, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride, Cinchonine DerivativeAlkylation, Alkylation Annulation of alkyl dihalides, oxindoles, alkyl dihalides, spiropentyl oxindoles, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-(((tert-butoxycarbonyl)-D-valyl)oxy)(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeSpirocyclization Oxohydroxylation, alpha-alkyl enoates, potassium permanganate, alpha-hydroxy-beta-ketoesters, (1S,2R,4S,5R)-2-((S)-((2-bromo-3,5-di-tert-butylbenzyl)oxy)(quinolin-4-yl)methyl)-1-(3,5-difluorobenzyl)-5-vinylquinuclidin-1-ium, Cinchonine DerivativeFurther reactions, Oxohydroxylation Michael Addition, (E)-1-fluoro-4-(2-nitrovinyl)benzene, dimethyl malonate, dimethyl (R)-2-(1-(4-fluorophenyl)-2-nitroethyl)malonate, 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea, Cinchonine DerivativeMichael, Michael Addition Dynamic kinetic resolution, 2-formylbenzoic acid, phthalidyl esters, Cinchonine BaseDynamic Kinetic Resolution, Resolution« Older EntriesNext Entries »
Michael Addition, maleimides, aldehydes, 2-(1-substituted-2,5-dioxopyrrolidin-3-yl)-2-substituted-acetaldehyde, (9R)-Cinchonan-9-amine, triphenylphosphine, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, unprotected 3-substituted oxindoles, beta-substituted nitroalkenes, 5-substituted-3-substituted-3-(1-nitroalkan-2-yl)indolin-2-one, Diethyl N-(9R)-cinchonan-9-ylphosphoramidate, Cinchonine DerivativeMichael, Michael Addition
Trifluoromethylation of aryl ketones, aryl ketones, trimethyl(trifluoromethyl)silane, trifluoromethyl-substituted aryl alcohols, (1S,1’S,2R,2’R,4S,4’S,5R,5’R)-1,1′-(1,3-phenylenebis(methylene))bis(2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium) bromide, tetramethylammonium fluoride, Cinchonine DerivativeTrifluoromethylation
Desymmetrization of aziridines with phosphites, (7-azabicyclo[4.1.0]heptan-7-yl)(pyridin-2-yl)methanone (aziridine), diphenyl phosphonate (phosphite), diphenyl ((1R,2R)-2-(picolinamido)cyclohexyl)phosphonate, N-(9R)-Cinchonan-9-yl-2-pyridinecarboxamide, Cinchonine DerivativeDesymmetrization
Intramolecular aza-Michael, N-(2-((4′-fluoro-4-oxo-[1,1′-biphenyl]-1(4H)-yl)oxy)ethyl)-4-methylbenzenesulfonamide (cyclohexadienones), (4S,4aS,8aS)-8a-(4-fluorophenyl)-4-tosyl-3,4,4a,8a-tetrahydro-2H-4lambda4-benzo[b][1,4]oxazin-6(5H)-one (morpholine derivative), 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea, Cinchonine DerivativeAza-Michael, Intramolecular Aza-Michael, Michael Addition
Alkylation, alpha-monosubstituted malonic diesters, alkyl dihalides, alpha,alpha-disubstituted malonic diesters, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride, Cinchonine DerivativeAlkylation, Alkylation
Annulation of alkyl dihalides, oxindoles, alkyl dihalides, spiropentyl oxindoles, (1S,2R,4S,5R)-1-(anthracen-9-ylmethyl)-2-((S)-(((tert-butoxycarbonyl)-D-valyl)oxy)(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Cinchonine DerivativeSpirocyclization
Oxohydroxylation, alpha-alkyl enoates, potassium permanganate, alpha-hydroxy-beta-ketoesters, (1S,2R,4S,5R)-2-((S)-((2-bromo-3,5-di-tert-butylbenzyl)oxy)(quinolin-4-yl)methyl)-1-(3,5-difluorobenzyl)-5-vinylquinuclidin-1-ium, Cinchonine DerivativeFurther reactions, Oxohydroxylation
Michael Addition, (E)-1-fluoro-4-(2-nitrovinyl)benzene, dimethyl malonate, dimethyl (R)-2-(1-(4-fluorophenyl)-2-nitroethyl)malonate, 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea, Cinchonine DerivativeMichael, Michael Addition
Dynamic kinetic resolution, 2-formylbenzoic acid, phthalidyl esters, Cinchonine BaseDynamic Kinetic Resolution, Resolution
