Alpha-Alkylation, tert-butyl 2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, 1-(bromomethyl)-4-fluorobenzene, tert-butyl (R)-4-(4-fluorobenzyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)-1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, substituted 3-(bromomethyl)-1H-indole, substituted tert-butyl (S)-2-((diphenylmethylene)amino)-3-(1H-indol-3-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromo-2-methylprop-1-ene, tert-butyl (S)-2-((diphenylmethylene)amino)-4-methylpent-4-enoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 10-(bromomethyl)-2,3,6-trimethoxyphenanthrene, tert-butyl (S)-2-((diphenylmethylene)amino)-3-(3,6,7-trimethoxyphenanthren-9-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 2-(benzyloxy)-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one, tert-butyl 3-(bromomethyl)-1H-indole-1-carboxylate, tert-butyl (S)-3-(2-(benzyloxy)-3-(1-methyl-1H-imidazol-2-yl)-3-oxopropyl)-1H-indole-1-carboxylate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-hydroxy-1-[2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl]-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation Thiolation, N-protected ethyl 2-imino-4-phenylbut-3-ynoate, 3-((trimethylsilyl)oxy)propane-1-thiol, N-protected ethyl (R)-2-amino-2-((3-hydroxypropyl)thio)-4-phenylbut-3-ynoate, diethylzinc, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-pyridinecarboxamide, Dihydrocinchonidine DerivativeFurther reactions, Thiolation Aza-Mannich reaction, 2-isocyanoacetates, imines, substituted 4,5-dihydro-1H-imidazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydrocinchonidine DerivativeAza-Mannich, Cyclization, Cyclization, Further Cyclizations, Mannich« Older EntriesNext Entries »
Alpha-Alkylation, tert-butyl 2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, 1-(bromomethyl)-4-fluorobenzene, tert-butyl (R)-4-(4-fluorobenzyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)-1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, substituted 3-(bromomethyl)-1H-indole, substituted tert-butyl (S)-2-((diphenylmethylene)amino)-3-(1H-indol-3-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromo-2-methylprop-1-ene, tert-butyl (S)-2-((diphenylmethylene)amino)-4-methylpent-4-enoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 10-(bromomethyl)-2,3,6-trimethoxyphenanthrene, tert-butyl (S)-2-((diphenylmethylene)amino)-3-(3,6,7-trimethoxyphenanthren-9-yl)propanoate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 2-(benzyloxy)-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one, tert-butyl 3-(bromomethyl)-1H-indole-1-carboxylate, tert-butyl (S)-3-(2-(benzyloxy)-3-(1-methyl-1H-imidazol-2-yl)-3-oxopropyl)-1H-indole-1-carboxylate, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-hydroxy-1-[2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl]-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation
Thiolation, N-protected ethyl 2-imino-4-phenylbut-3-ynoate, 3-((trimethylsilyl)oxy)propane-1-thiol, N-protected ethyl (R)-2-amino-2-((3-hydroxypropyl)thio)-4-phenylbut-3-ynoate, diethylzinc, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-pyridinecarboxamide, Dihydrocinchonidine DerivativeFurther reactions, Thiolation
Aza-Mannich reaction, 2-isocyanoacetates, imines, substituted 4,5-dihydro-1H-imidazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydrocinchonidine DerivativeAza-Mannich, Cyclization, Cyclization, Further Cyclizations, Mannich
