Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-hydroxy-1-[2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl]-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation Thiolation, N-protected ethyl 2-imino-4-phenylbut-3-ynoate, 3-((trimethylsilyl)oxy)propane-1-thiol, N-protected ethyl (R)-2-amino-2-((3-hydroxypropyl)thio)-4-phenylbut-3-ynoate, diethylzinc, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-pyridinecarboxamide, Dihydrocinchonidine DerivativeFurther reactions, Thiolation Aza-Mannich reaction, 2-isocyanoacetates, imines, substituted 4,5-dihydro-1H-imidazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydrocinchonidine DerivativeAza-Mannich, Cyclization, Cyclization, Further Cyclizations, Mannich Amination, diethyl acetylphosphonate, (2-chlorophenyl)methanamine, diethyl (1-aminoethyl)phosphonate, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivativealpha-Amination, Amination, Phosphination Henry reaction, 2-(2,3-dioxoindolin-4-yl)benzaldehyde, nitromethane, oxindole-based bridged biaryls, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Henry, Henry Amination, substituted diisopropyl acetylphosphonate, amides, arylmethanamines, sulfurous dichloride, triisopropyl phosphite, substituted diisopropyl (aminomethyl)phosphonate, (8α,9R)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,3′′-terphenyl]-5′-yl]methyl]-6′-hydroxy-cinchonanium bromide, Cupreine DerivativeAmination Oxa-Michael Addition, ethyl 2-(3,5-dimethylphenyl)-3-nitroacrylate, oximes, ethyl 2-(3,5-dimethylphenyl)-2-(((4-methoxybenzylidene)amino)oxy)-3-nitropropanoate, (9S)-9-[[4-(1,1-dimethylethyl)phenyl]methoxy]-cinchonan-6′-ol, Cupreidine DerivativeMichael Addition, Oxa-Michael Addition Michael Addition, 1-(2,5-dimethoxyphenyl)-3-nitroprop-2-en-1-one, methyl 3-(hydroxymethyl)-2-oxocyclohex-3-ene-1-carboxylate, methyl 2-(2,5-dimethoxybenzoyl)-5-(hydroxymethyl)-3-nitro-6-oxobicyclo[2.2.2]octane-1-carboxylate, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition« Older EntriesNext Entries »
Alpha-Alkylation, 1-(1-methyl-1H-imidazol-2-yl)-2-(naphthalen-2-ylmethoxy)ethan-1-one, 2-(bromomethyl)naphthalene, (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(naphthalen-2-yl)-2-(naphthalen-2-ylmethoxy)propan-1-one, (8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alpha-Alkylation, 2-substituted tert-butyl 4,5-dihydrothiazole-4-carboxylate, allyl bromide, substituted tert-butyl (S)-4-allyl-4,5-dihydrothiazole-4-carboxylate, (8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro- 9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzyl bromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-hydroxy-1-[2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl]-cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, Alkylation
Thiolation, N-protected ethyl 2-imino-4-phenylbut-3-ynoate, 3-((trimethylsilyl)oxy)propane-1-thiol, N-protected ethyl (R)-2-amino-2-((3-hydroxypropyl)thio)-4-phenylbut-3-ynoate, diethylzinc, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-pyridinecarboxamide, Dihydrocinchonidine DerivativeFurther reactions, Thiolation
Aza-Mannich reaction, 2-isocyanoacetates, imines, substituted 4,5-dihydro-1H-imidazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydrocinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydrocinchonidine DerivativeAza-Mannich, Cyclization, Cyclization, Further Cyclizations, Mannich
Amination, diethyl acetylphosphonate, (2-chlorophenyl)methanamine, diethyl (1-aminoethyl)phosphonate, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivativealpha-Amination, Amination, Phosphination
Henry reaction, 2-(2,3-dioxoindolin-4-yl)benzaldehyde, nitromethane, oxindole-based bridged biaryls, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Henry, Henry
Amination, substituted diisopropyl acetylphosphonate, amides, arylmethanamines, sulfurous dichloride, triisopropyl phosphite, substituted diisopropyl (aminomethyl)phosphonate, (8α,9R)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,3′′-terphenyl]-5′-yl]methyl]-6′-hydroxy-cinchonanium bromide, Cupreine DerivativeAmination
Oxa-Michael Addition, ethyl 2-(3,5-dimethylphenyl)-3-nitroacrylate, oximes, ethyl 2-(3,5-dimethylphenyl)-2-(((4-methoxybenzylidene)amino)oxy)-3-nitropropanoate, (9S)-9-[[4-(1,1-dimethylethyl)phenyl]methoxy]-cinchonan-6′-ol, Cupreidine DerivativeMichael Addition, Oxa-Michael Addition
Michael Addition, 1-(2,5-dimethoxyphenyl)-3-nitroprop-2-en-1-one, methyl 3-(hydroxymethyl)-2-oxocyclohex-3-ene-1-carboxylate, methyl 2-(2,5-dimethoxybenzoyl)-5-(hydroxymethyl)-3-nitro-6-oxobicyclo[2.2.2]octane-1-carboxylate, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition
