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Asymmetric Isomerization, beta,beta-difluoro-alpha-imine amides, beta,beta-difluoro-alpha-amino amides, 4-((R)-(isopentyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-ol, Cupreine Derivative

Isomerization

Michael Addition, methyl 2-oxocyclopentane-1-carboxylate, (E)-(2-nitrovinyl)benzene, methyl (S)-1-((R)-2-nitro-1-phenylethyl)-2-oxocyclopentane-1-carboxylate, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivative

Michael, Michael Addition

Henry reaction (Nitroaldol), 2-(5-bromopyridin-2-yl)-1-(2,4-difluorophenyl)-2,2-difluoroethan-1-one, nitromethane, (R)-1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-nitropropan-2-ol, Cupreine Base

Aldol, Henry, Henry, Nitroaldol

Michael Addition, ethyl 2-oxocyclohexane-1-carboxylate, (E)-(2-nitrovinyl)benzene, ethyl (S)-1-((R)-2-nitro-1-phenylethyl)-2-oxocyclohexane-1-carboxylate, Cupreine Base

Michael, Michael Addition

Friedel-Crafts reaction, isatins, 1H-indoles, substituted (S)-3-hydroxy-3-(1H-indol-3-yl)indolin-2-ones, Cupreine Base

Friedel-Crafts, Friedel-Crafts reaction

Michael Addition, ethyl 2-nitrobutanoate, (E)-(2-nitrovinyl)benzene, ethyl 2-ethyl-2,4-dinitro-3-phenylbutanoate, Cupreine Base

Michael, Michael Addition

Mannich reaction, beta-dicarbonyl compounds, alpha-amido sulfones, beta-amino ketones, Cinchonine Base

Mannich, Mannich

Aldol reaction, aldehydes, ethyl 2-diazoacetate, alpha-diazo-beta-hydroxy esters, (S)-BINOL, Tetraisopropyl Titanate, Quinidine Base

Aldol, Aldol

Aldol reaction, aldehydes, ethyl 2-diazoacetate, alpha-diazo-beta-hydroxy esters, (S)-BINOL, Tetraisopropyl Titanate, Cinchonine Base

Aldol, Aldol

Cyanation, aldehydes or ketones, trimethylsilyl cyanide or ethyl cyanoformate, alpha-hydroxynitriles, substituted 2,2-Biphenol, Tetraisopropyl Titanate, Quinidine Base

Cyanation

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