Cyanation, activated olefins, ethyl cyanoformate, R-substituted diethyl 2-(1-cyanomethyl)malonate, Tetraisopropyl Titanate, 3,3′-disubstituted-[1,1′-biphenyl]-2,2′-diol, Quinidine BaseCyanation, Michael, Michael Addition Vinylogous Michael Addition, alpha,beta-unsaturated γ-butyrolactam, nitroolefins, 1R-substituted tert-butyl (R)-2-(2-nitroethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, Quinidine BaseMichael Addition, Vinylogous Michael Addition Protonation, alpha‐oxygenated ester enolates, disubstituted phosphonic acid, substituted (R)-2-(phosphonooxy)propanoate, Quinidine BaseProtonation Sulfenylation, 3-substituted oxindoles, substituted 2-(phenylthio)isoindoline-1,3-dione, substituted tert-butyl (R)-2-oxo-3-phenyl-3-(phenylthio)indoline-1-carboxylate, Quinidine BaseSulfenylation Michael Addition, substituted (E)-3-(prop-1-en-1-yl)benzo[d]isothiazole 1,1-dioxide, malononitrile, (9S)-substituted 7-amino–9H-benzo[4,5]isothiazolo[2,3-a]pyridine-8-carbonitrile 5,5-dioxide, Quinidine BaseAza-Michael, Cyclization, Cyclization, Further Cyclizations, Michael Addition NH-Insertion, phenyldiazoacetates, anilines, N-substituted isobutyl 2-amino-2-phenylacetate, rhodium bis(triphenylacetate) dimer, Dihydrocinchonine BaseAmination Michael Addition, alpha,beta-enone, nitromethane, (R)-baclofen, (9R)-1-(9-anthracenylmethyl)-10,11-dihydro-9-(phenylmethoxy)-cinchonanium bromide, Dihydrocinchonine DerivativeMichael, Michael Addition Alkylation, substituted (Z)-4-chlorobut-3-en-2-one, alpha-substituted-alpha-cyanoacetates, substituted tert-butyl (R,Z)-2-cyano-5-oxohex-3-enoate, (9S)-(9′′S)-1,1′′-[1,3-phenylenebis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium dibromide, Dihydrocinchonine DerivativeAlkylation, Alkylation Oxotrifluoromethylation, 1,3-substituted but-3-enal oxime, 3,3-dimethyl-1-(trifluoromethyl)-1,3-dihydro-1l3-benzo[d][1,2]iodaoxole, cyclic alkenyl oximes, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Trifluoromethylation Alkynylation, cyclic beta-ketoesters, allyl 3-bromopropiolate, tert-butyl (S)-2-(3-(allyloxy)-3-oxoprop-1-yn-1-yl)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-(9-anthracenylmethyl)-10,11-dihydro-9-[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)oxy]-cinchonanium chloride, Dihydrocinchonine DerivativeAlkynylation« Older EntriesNext Entries »
Cyanation, activated olefins, ethyl cyanoformate, R-substituted diethyl 2-(1-cyanomethyl)malonate, Tetraisopropyl Titanate, 3,3′-disubstituted-[1,1′-biphenyl]-2,2′-diol, Quinidine BaseCyanation, Michael, Michael Addition
Vinylogous Michael Addition, alpha,beta-unsaturated γ-butyrolactam, nitroolefins, 1R-substituted tert-butyl (R)-2-(2-nitroethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, Quinidine BaseMichael Addition, Vinylogous Michael Addition
Protonation, alpha‐oxygenated ester enolates, disubstituted phosphonic acid, substituted (R)-2-(phosphonooxy)propanoate, Quinidine BaseProtonation
Sulfenylation, 3-substituted oxindoles, substituted 2-(phenylthio)isoindoline-1,3-dione, substituted tert-butyl (R)-2-oxo-3-phenyl-3-(phenylthio)indoline-1-carboxylate, Quinidine BaseSulfenylation
Michael Addition, substituted (E)-3-(prop-1-en-1-yl)benzo[d]isothiazole 1,1-dioxide, malononitrile, (9S)-substituted 7-amino–9H-benzo[4,5]isothiazolo[2,3-a]pyridine-8-carbonitrile 5,5-dioxide, Quinidine BaseAza-Michael, Cyclization, Cyclization, Further Cyclizations, Michael Addition
NH-Insertion, phenyldiazoacetates, anilines, N-substituted isobutyl 2-amino-2-phenylacetate, rhodium bis(triphenylacetate) dimer, Dihydrocinchonine BaseAmination
Michael Addition, alpha,beta-enone, nitromethane, (R)-baclofen, (9R)-1-(9-anthracenylmethyl)-10,11-dihydro-9-(phenylmethoxy)-cinchonanium bromide, Dihydrocinchonine DerivativeMichael, Michael Addition
Alkylation, substituted (Z)-4-chlorobut-3-en-2-one, alpha-substituted-alpha-cyanoacetates, substituted tert-butyl (R,Z)-2-cyano-5-oxohex-3-enoate, (9S)-(9′′S)-1,1′′-[1,3-phenylenebis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium dibromide, Dihydrocinchonine DerivativeAlkylation, Alkylation
Oxotrifluoromethylation, 1,3-substituted but-3-enal oxime, 3,3-dimethyl-1-(trifluoromethyl)-1,3-dihydro-1l3-benzo[d][1,2]iodaoxole, cyclic alkenyl oximes, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Trifluoromethylation
Alkynylation, cyclic beta-ketoesters, allyl 3-bromopropiolate, tert-butyl (S)-2-(3-(allyloxy)-3-oxoprop-1-yn-1-yl)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-(9-anthracenylmethyl)-10,11-dihydro-9-[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)oxy]-cinchonanium chloride, Dihydrocinchonine DerivativeAlkynylation
