A new reagent for the preparation of chiral HMGA (3-hydroxy-3-methylglutaric acid) esters and amides. Synthesis of (R)- and (S)-β-carboxymethyl-β-methyl-β-lactones by asymmetric desymmetrization of HMGA anhydride.

DOI Number:

10.1016/0040-4039(96)00274-2

Reaction Category:

Educt:

4-hydroxy-4-methyldihydro-2H-pyran-2,6(3H)-dione

Product:

(R)-2-(2-methyl-4-oxooxetan-2-yl)acetic acid

Catalyst:

Dihydroquinine Base

Cas No:

522-66-7

Cas No:

522-66-7