Sulfenylation, ethyl 1-benzyl-4-(4-chlorobenzyl)-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate, 1-(phenylthio)pyrrolidine-2,5-dione, alpha‐sulfenylated carbonyl compounds, (9S)-(9′′S)-9,9′′-[1,4-phthalazinediylbis(oxy)]bis[6′-methoxy-cinchonan, Quinidine DerivativeSulfenylation Nitro-Mannich, substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, (1R,2S)-1,2-disubstituted tert-butyl (2-nitroethyl)carbamate, (9R)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinidine DerivativeMannich, Nitro-Mannich Addition, aldehydes, diethylzinc, (R)-1-substituted propan-1-ol, N-[(9R)-6′-methoxycinchonan-9-yl]-P,P- diphenyl-phosphinic amide, Quinidine DerivativeAddition Spirocyclization, substituted (E)-6-(4-hydroxyphenyl)hex-3-en-2-one, cyclohexadienone containing hindered spirocyclic ethers, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[[(1R)-1-phenylethyl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeDearomatization, Further reactions, Michael Addition, Oxa-Michael Addition, Spirocyclization Arylation, 2-phenyl-4H-chromen-4-one, 4-Pyridincarbonitril, (S)-2-phenyl-2-(pyridin-4-yl)chroman-4-one, N,N′-bis[(9R)-6′-methoxycinchonan-9-yl]-thiourea, Quinidine DerivativeArylation, Further reactions Cylcopropanation, benzofulvenes, dimethyl 2-bromomalonate, dimethyl (1R,3S)-3′-cyano-3-phenylspiro[cyclopropane-1,1′-indene]-2,2-dicarboxylate, (9S)-9-(benzoyloxy)-6′-methoxy-1-[(4-nitrophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeCyclopropanation, Spirocyclization Fluorination, beta-ketoesters, selectfluor, 1-substituted pyrrole-2,5-dione, substituted ethyl (S)-2-((S)-2,5-dioxopyrrolidin-3-yl)-2-fluoro-3-oxobutanoate, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Quinidine Derivativealpha-Fluorination, Desymmetrization, Fluorination, Michael, Michael Addition Spirocyclization, 2-oxocyclohexane-1-carbaldehyde, aliphatic beta,gamma-unsaturated α-keto esters, substituted (6R)-1,7-dioxo-2-oxaspiro[5.5]undecane-3-carboxylate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization Spirocyclization, alpha‐cyano ketones, isatylidene malononitriles, Spiro [4H‐pyran‐oxindoles], N-[(1S,2S)-2-[[[[(9R)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-methanesulfonamide, Quinidine DerivativeMichael, Michael Addition, Spirocyclization Spirocyclization, 3-isothiocyanato oxindoles, 3-trifluoroethylidene oxindoles, 3′-trifluoromethyl substituted 3, 2′-pyrrolidinyl-bispirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization« Older EntriesNext Entries »
Sulfenylation, ethyl 1-benzyl-4-(4-chlorobenzyl)-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate, 1-(phenylthio)pyrrolidine-2,5-dione, alpha‐sulfenylated carbonyl compounds, (9S)-(9′′S)-9,9′′-[1,4-phthalazinediylbis(oxy)]bis[6′-methoxy-cinchonan, Quinidine DerivativeSulfenylation
Nitro-Mannich, substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, (1R,2S)-1,2-disubstituted tert-butyl (2-nitroethyl)carbamate, (9R)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinidine DerivativeMannich, Nitro-Mannich
Addition, aldehydes, diethylzinc, (R)-1-substituted propan-1-ol, N-[(9R)-6′-methoxycinchonan-9-yl]-P,P- diphenyl-phosphinic amide, Quinidine DerivativeAddition
Spirocyclization, substituted (E)-6-(4-hydroxyphenyl)hex-3-en-2-one, cyclohexadienone containing hindered spirocyclic ethers, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[[(1R)-1-phenylethyl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeDearomatization, Further reactions, Michael Addition, Oxa-Michael Addition, Spirocyclization
Arylation, 2-phenyl-4H-chromen-4-one, 4-Pyridincarbonitril, (S)-2-phenyl-2-(pyridin-4-yl)chroman-4-one, N,N′-bis[(9R)-6′-methoxycinchonan-9-yl]-thiourea, Quinidine DerivativeArylation, Further reactions
Cylcopropanation, benzofulvenes, dimethyl 2-bromomalonate, dimethyl (1R,3S)-3′-cyano-3-phenylspiro[cyclopropane-1,1′-indene]-2,2-dicarboxylate, (9S)-9-(benzoyloxy)-6′-methoxy-1-[(4-nitrophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeCyclopropanation, Spirocyclization
Fluorination, beta-ketoesters, selectfluor, 1-substituted pyrrole-2,5-dione, substituted ethyl (S)-2-((S)-2,5-dioxopyrrolidin-3-yl)-2-fluoro-3-oxobutanoate, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Quinidine Derivativealpha-Fluorination, Desymmetrization, Fluorination, Michael, Michael Addition
Spirocyclization, 2-oxocyclohexane-1-carbaldehyde, aliphatic beta,gamma-unsaturated α-keto esters, substituted (6R)-1,7-dioxo-2-oxaspiro[5.5]undecane-3-carboxylate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
Spirocyclization, alpha‐cyano ketones, isatylidene malononitriles, Spiro [4H‐pyran‐oxindoles], N-[(1S,2S)-2-[[[[(9R)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-methanesulfonamide, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
Spirocyclization, 3-isothiocyanato oxindoles, 3-trifluoroethylidene oxindoles, 3′-trifluoromethyl substituted 3, 2′-pyrrolidinyl-bispirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
