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alpha-Fluorination, acid chlorides, N-fluorbenzolsulfonimid, methanol, methyl (R)-2-fluoro-2-(4-methoxyphenyl)acetate, Dichloro[1,1′-(1,3-propanediyl)bis[1,1-diphenylphosphine-κP]]nickel, 6′-methoxy-(9S)-Cinchonan-9-ol-9-benzoate, Quinidine Derivative

alpha-Fluorination, Fluorination

[8+3]-Cycloaddition, 2-(2-oxopropyl)cyclopropane-1,1-dicarbonitrile, Tropone, (R)-2-(2-oxopropyl)-2,3-dihydrocyclohepta[b]pyran-4,4(9H)-dicarbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine Derivative

[8+3]-Cycloaddition, Cycloaddition

Mannich reaction, ketones, ethyl (E)-2-((4-methoxyphenyl)imino)acetate, 3,3,4-trisubstituted ethyl (R)-2-((4-methoxyphenyl)amino)-4-oxobutanoate, (R)-pyrrolidine-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine Derivative

Mannich, Mannich

Cyanation, beta-trifluoromethylated chalcones, 2-hydroxy-2-methylpropanenitrile, (R)-4-oxo-2,4-diphenyl-2-(trifluoromethyl)butanenitrile, (9S)-1-[[2,5-bis(trifluoromethyl)phenyl]methyl]-6′,9-dimethoxy-cinchonanium bromide, Quinidine Derivative

Cyanation, Michael, Michael Addition

Michael Addition, chalcones, nitromethane, 1,3-disubstituted 4-nitrobutan-1-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine Derivative

Michael, Michael Addition

Epoxidation, ((chloromethyl)sulfonyl)benzene, aldehydes, (2R)-substituted (3R)-3-(phenylsulfonyl)oxirane, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine Derivative

Epoxidation

Friedel-Crafts, naphthalen-1-ol, tert-butyl (Z)-(1-benzyl-2-oxoindolin-3-ylidene)carbamate, tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxoindolin-3-yl)carbamate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine Derivative

Friedel-Crafts, Friedel-Crafts alkylation

Cyclization, substituted (E)-2-acetylbut-2-enenitrile, cyclohexanone, 2,4-disubstituted (4R,4aS,8aR)-8a-hydroxy-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carbonitrile, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine Derivative

Cyclization, Cyclization, Further Cyclizations, Michael Addition

[4+2]-Cycloaddition, beta-substituted cyclic enones, polyconjugated malononitriles, substituted (1R,3S,4R)-1-methyl-5-oxo-3-((E)-prop-1-en-1-yl)bicyclo[2.2.2]octane-2,2-dicarbonitrile, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine Derivative

[4+2]-Cycloaddition, Cycloaddition, Diels-Alder reaction

Michael Addition, isatylidine malononitriles, methylketones, substituted (R)-2-(2-oxo-3-(2-oxopropyl)indolin-3-yl)malononitrile, 1,1′-Binaphthyl-2,2′-diyl hydrogen phosphate, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine Derivative

Michael, Michael Addition

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