Mannich reaction, 3-(2,4-dioxopentan-3-yl)-1,1-dimethylurea, benzyl ((1Z,2E)-3-phenylallylidene)carbamate, benzyl (R,E)-(4-acetyl-4-(3,3-dimethylureido)-5-oxo-1-phenylhex-1-en-3-yl)carbamate, Cinchonidine BaseMannich, Mannich Dynamic kinetic resolution, 2,2,2-triphenyl-N-(p-tolylsulfinyl)acetamide, 2,2-dimethylpropan-1-ol, [S(R)]-4-methyl-N-(2,2,2-triphenylacetyl)-Benzenesulfinimidic acid 2,2-dimethylpropyl ester, Cinchonidine BaseDynamic Kinetic Resolution, Resolution Tandem Michael-Knoevenagel, 2-mercaptobenzaldehyde, diethyl 2-(2-methoxybenzylidene)malonate, substituted thiochromanes, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction Hydrophosphonylation, trifluoromethyl 2(1H)-quinazolinones, dimethyl phosphonate, 4,4-disubstituted 2(1H)-quinazolinones, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeHydrophosphonylation Mannich reaction, methyl 3-oxo-2,3-dihydrobenzofuran-2-carboxylate, tert-butyl (E)-(1-methyl-2-oxoindolin-3-ylidene)carbamate, tetrasubstituted stereocenter containing 3-aminooxindole, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich Phosphination, 1,2 disubstituted 2-diazoethan-1-one, disubstituted phosphine oxide, substituted (2-hydroxyethyl)phosphine oxide, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeFurther reactions, Phosphination Amination, substituted 3-oxopropanamide, di-tert-butyl (E)-diazene-1,2-dicarboxylate, serines, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Amination, Amination Spirocyclization, oxindoles, pyrazolones, bi-spirocyclic compounds, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Spirocyclization Spirocyclization, β,γ-unsaturated amides, oxindoles, spirooxindole-pyran derivatives, N-[(1S,2S)-2-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-4-methyl-benzenesulfonamide, Quinine DerivativeCycloaddition, Diels-Alder reaction, Spirocyclization Spirocyclization, enone-tethered 2,5-cyclohexadienone, isoxazolines, spiro-fused scaffolds, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization« Older EntriesNext Entries »
Mannich reaction, 3-(2,4-dioxopentan-3-yl)-1,1-dimethylurea, benzyl ((1Z,2E)-3-phenylallylidene)carbamate, benzyl (R,E)-(4-acetyl-4-(3,3-dimethylureido)-5-oxo-1-phenylhex-1-en-3-yl)carbamate, Cinchonidine BaseMannich, Mannich
Dynamic kinetic resolution, 2,2,2-triphenyl-N-(p-tolylsulfinyl)acetamide, 2,2-dimethylpropan-1-ol, [S(R)]-4-methyl-N-(2,2,2-triphenylacetyl)-Benzenesulfinimidic acid 2,2-dimethylpropyl ester, Cinchonidine BaseDynamic Kinetic Resolution, Resolution
Tandem Michael-Knoevenagel, 2-mercaptobenzaldehyde, diethyl 2-(2-methoxybenzylidene)malonate, substituted thiochromanes, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction
Hydrophosphonylation, trifluoromethyl 2(1H)-quinazolinones, dimethyl phosphonate, 4,4-disubstituted 2(1H)-quinazolinones, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeHydrophosphonylation
Mannich reaction, methyl 3-oxo-2,3-dihydrobenzofuran-2-carboxylate, tert-butyl (E)-(1-methyl-2-oxoindolin-3-ylidene)carbamate, tetrasubstituted stereocenter containing 3-aminooxindole, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich
Phosphination, 1,2 disubstituted 2-diazoethan-1-one, disubstituted phosphine oxide, substituted (2-hydroxyethyl)phosphine oxide, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeFurther reactions, Phosphination
Amination, substituted 3-oxopropanamide, di-tert-butyl (E)-diazene-1,2-dicarboxylate, serines, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Amination, Amination
Spirocyclization, oxindoles, pyrazolones, bi-spirocyclic compounds, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Spirocyclization
Spirocyclization, β,γ-unsaturated amides, oxindoles, spirooxindole-pyran derivatives, N-[(1S,2S)-2-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-4-methyl-benzenesulfonamide, Quinine DerivativeCycloaddition, Diels-Alder reaction, Spirocyclization
Spirocyclization, enone-tethered 2,5-cyclohexadienone, isoxazolines, spiro-fused scaffolds, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization
