Mannich reaction, tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates, S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate), 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMannich, Mannich Spirocyclization, 4-alkylideneisoxazol-5-ones, methyl vinyl ketones, 6,10-disubstituted (6S,10S)-4-methyl-2-oxa-3-azaspiro[4.5]dec-3-ene-1,8-dione, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeSpirocyclization Allylic Alkylation, (E)-1,3-diphenylallyl acetate, dimethyl malonate, dimethyl (R,E)-2-(1,3-diphenylallyl)malonate, Di-μ-chlorobis(η3-2-propenyl)dipalladium, (8α,9R)-9-[[(4S,5S)-4,5-Diphenyl-1,3,2-dioxaphospholan-2-yl]oxy]cinchonan, Cinchonidine DerivativeAlkylation, Allylic Alkylation Oxysulfonylation, β,γ-unsaturated ketoximes, sulfonyl chlorides, sulfonyl-containing isoxazolines, cupric acetate, N-(8α,9S)-Cinchonan-9-yl-2,3,5,6-tetramethylbenzenesulfonamide, Cinchonidine DerivativeCyclization, Further reactions, Isoxazoline cyclization, Oxysulfonylation, Sulfonylation Oxa-Michael, 2,4-disubstituted tert-butyl (Z)-4-oxobut-2-enoate, hydroxylamine, carboxy-substituted 2-isoxazolines, (1S,2R,4S,5R)-1-(2,5-bis(trifluoromethyl)benzyl)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition Intramolecular Hydroarylation, 1-((2-(1-methyl-1H-indol-2-yl)phenyl)ethynyl)naphthalen-2-ol, 1-(11-methyl-11H-benzo[a]carbazol-6-yl)naphthalen-2-ol, Cinchonidine BaseCyclization, Further Cyclizations, Intramolecular cyclization Oxa-Michael, (E)-4,4,4-trifluoro-1,3-diphenylbut-2-en-1-one, hydroxylamine, trifluoromethyl‐substituted 2‐isoxazolines, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition Synthesis of N-N axially coumpounds, N-(4-oxo-2-substituted-quinazolin-3(4H)-yl)substituted-amide, substituted Methylbromide, N-substituted-N-(2-substituted-4-oxoquinazolin-3(4H)-yl)substituted-amide, 1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-9-[[[[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino]carbonyl]amino]-Cinchoanium bromide, Cinchonidine DerivativeSynthesis of N-N axially compounds Michael Addition, β‐silylmethylene malonate, 2-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, diethyl (R)-2-((5-acetoxy-1-(4-bromophenyl)-3-methyl-1H-pyrazol-4-yl)(1,1,3,3,3-pentamethyldisiloxaneyl)methyl)malonate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition Michael Addition, beta‐silylmethylene malonates, nitromethane, diethyl (R)-2-(1-(dimethyl(phenyl)silyl)-2-nitroethyl)malonate, N-[(9R)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-Thiourea, Quinidine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Mannich reaction, tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates, S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate), 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMannich, Mannich
Spirocyclization, 4-alkylideneisoxazol-5-ones, methyl vinyl ketones, 6,10-disubstituted (6S,10S)-4-methyl-2-oxa-3-azaspiro[4.5]dec-3-ene-1,8-dione, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeSpirocyclization
Allylic Alkylation, (E)-1,3-diphenylallyl acetate, dimethyl malonate, dimethyl (R,E)-2-(1,3-diphenylallyl)malonate, Di-μ-chlorobis(η3-2-propenyl)dipalladium, (8α,9R)-9-[[(4S,5S)-4,5-Diphenyl-1,3,2-dioxaphospholan-2-yl]oxy]cinchonan, Cinchonidine DerivativeAlkylation, Allylic Alkylation
Oxysulfonylation, β,γ-unsaturated ketoximes, sulfonyl chlorides, sulfonyl-containing isoxazolines, cupric acetate, N-(8α,9S)-Cinchonan-9-yl-2,3,5,6-tetramethylbenzenesulfonamide, Cinchonidine DerivativeCyclization, Further reactions, Isoxazoline cyclization, Oxysulfonylation, Sulfonylation
Oxa-Michael, 2,4-disubstituted tert-butyl (Z)-4-oxobut-2-enoate, hydroxylamine, carboxy-substituted 2-isoxazolines, (1S,2R,4S,5R)-1-(2,5-bis(trifluoromethyl)benzyl)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition
Intramolecular Hydroarylation, 1-((2-(1-methyl-1H-indol-2-yl)phenyl)ethynyl)naphthalen-2-ol, 1-(11-methyl-11H-benzo[a]carbazol-6-yl)naphthalen-2-ol, Cinchonidine BaseCyclization, Further Cyclizations, Intramolecular cyclization
Oxa-Michael, (E)-4,4,4-trifluoro-1,3-diphenylbut-2-en-1-one, hydroxylamine, trifluoromethyl‐substituted 2‐isoxazolines, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition
Synthesis of N-N axially coumpounds, N-(4-oxo-2-substituted-quinazolin-3(4H)-yl)substituted-amide, substituted Methylbromide, N-substituted-N-(2-substituted-4-oxoquinazolin-3(4H)-yl)substituted-amide, 1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-9-[[[[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino]carbonyl]amino]-Cinchoanium bromide, Cinchonidine DerivativeSynthesis of N-N axially compounds
Michael Addition, β‐silylmethylene malonate, 2-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, diethyl (R)-2-((5-acetoxy-1-(4-bromophenyl)-3-methyl-1H-pyrazol-4-yl)(1,1,3,3,3-pentamethyldisiloxaneyl)methyl)malonate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition
Michael Addition, beta‐silylmethylene malonates, nitromethane, diethyl (R)-2-(1-(dimethyl(phenyl)silyl)-2-nitroethyl)malonate, N-[(9R)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-Thiourea, Quinidine DerivativeMichael, Michael Addition
