Desymmetrization, (3aR,7aS)-hexahydroisobenzofuran-1,3-dione, 2,2,2-trifluoroethan-1-ol, (1R,2S)-2-((2,2,2-trifluoroethoxy)carbonyl)cyclohexane-1-carboxylic acid, 2-[[(9S)-6′-methoxycinchonan-9-yl]oxy]-acetic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, Quinidine DerivativeDesymmetrization Michael Addition, beta,beta-disubstituted enones, nitromethane, 1,3-disubstituted (R)-4,4,4-trifluoro-3-(nitromethyl)-butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition Michael Addition, (E)-7-oxo-7-phenylhept-5-enal, (E)-(2-nitrovinyl)benzene, (1R,2S,3R,4R)-3-nitro-4-(2-oxo-2-phenylethyl)-2-phenylcyclohexane-1-carbaldehyde, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition Michael Addition, trans-β-nitrostyrene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)amino)-4-((((S)-2′-methyl-[1,1′-binaphthalen]-2-yl)methyl)amino)cyclobut-3-ene-1,2-dithione, Dihydroquinine DerivativeMichael, Michael Addition Michael Addition, butanone, (E)-(2-nitrovinyl)benzene, (3R,4S)-3-methyl-5-nitro-4-phenylpentan-2-one, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition Michael Addition, trans-β-nitrostyrene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-(((1S)-((2S,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)amino)-4-(R)-(((2′-methyl-[1,1′-binaphthalen]-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Michael Addition, enones, oxindoles, substituted (S)-3-methyl-3-((R)-4-oxopentan-2-yl)indolin-2-one, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeMichael, Michael Addition Atropisomer synthesis, 2′-methoxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, (S)-2-(benzyloxy)-2′-methoxy-1,1′-binaphthalene, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAtropisomer synthesis Trifluoromethylthiolation, Substituted (3E)-2-oxo-3-(substituted-methylene)cyclopentanecarboxylate, 1-((trifluoromethyl)thio)pyrrolidine-2,5-dione, 5-substituted 2-mercaptobenzaldehyde, spiro-cyclopentanone–thiochromanes, 3-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)amino]-3-cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction, Spirocyclization, Trifluoro-methylthiolation Desymmetrization, prochiral cyclic anhydrides, methanol, chiral hemiesters, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeDesymmetrization« Older EntriesNext Entries »
Desymmetrization, (3aR,7aS)-hexahydroisobenzofuran-1,3-dione, 2,2,2-trifluoroethan-1-ol, (1R,2S)-2-((2,2,2-trifluoroethoxy)carbonyl)cyclohexane-1-carboxylic acid, 2-[[(9S)-6′-methoxycinchonan-9-yl]oxy]-acetic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, Quinidine DerivativeDesymmetrization
Michael Addition, beta,beta-disubstituted enones, nitromethane, 1,3-disubstituted (R)-4,4,4-trifluoro-3-(nitromethyl)-butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition
Michael Addition, (E)-7-oxo-7-phenylhept-5-enal, (E)-(2-nitrovinyl)benzene, (1R,2S,3R,4R)-3-nitro-4-(2-oxo-2-phenylethyl)-2-phenylcyclohexane-1-carbaldehyde, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition
Michael Addition, trans-β-nitrostyrene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)amino)-4-((((S)-2′-methyl-[1,1′-binaphthalen]-2-yl)methyl)amino)cyclobut-3-ene-1,2-dithione, Dihydroquinine DerivativeMichael, Michael Addition
Michael Addition, butanone, (E)-(2-nitrovinyl)benzene, (3R,4S)-3-methyl-5-nitro-4-phenylpentan-2-one, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition
Michael Addition, trans-β-nitrostyrene, pentane-2,4-dione, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-(((1S)-((2S,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)amino)-4-(R)-(((2′-methyl-[1,1′-binaphthalen]-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Michael Addition, enones, oxindoles, substituted (S)-3-methyl-3-((R)-4-oxopentan-2-yl)indolin-2-one, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeMichael, Michael Addition
Atropisomer synthesis, 2′-methoxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, (S)-2-(benzyloxy)-2′-methoxy-1,1′-binaphthalene, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAtropisomer synthesis
Trifluoromethylthiolation, Substituted (3E)-2-oxo-3-(substituted-methylene)cyclopentanecarboxylate, 1-((trifluoromethyl)thio)pyrrolidine-2,5-dione, 5-substituted 2-mercaptobenzaldehyde, spiro-cyclopentanone–thiochromanes, 3-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)amino]-3-cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction, Spirocyclization, Trifluoro-methylthiolation
Desymmetrization, prochiral cyclic anhydrides, methanol, chiral hemiesters, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeDesymmetrization
