Amination, substituted diisopropyl acetylphosphonate, amides, arylmethanamines, sulfurous dichloride, triisopropyl phosphite, substituted diisopropyl (aminomethyl)phosphonate, (8α,9R)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,3′′-terphenyl]-5′-yl]methyl]-6′-hydroxy-cinchonanium bromide, Cupreine DerivativeAmination, Isomerization Oxa-Michael Addition, ethyl 2-(3,5-dimethylphenyl)-3-nitroacrylate, oximes, ethyl 2-(3,5-dimethylphenyl)-2-(((4-methoxybenzylidene)amino)oxy)-3-nitropropanoate, (9S)-9-[[4-(1,1-dimethylethyl)phenyl]methoxy]-cinchonan-6′-ol, Cupreidine DerivativeMichael Addition, Oxa-Michael Addition Michael Addition, 1-(2,5-dimethoxyphenyl)-3-nitroprop-2-en-1-one, methyl 3-(hydroxymethyl)-2-oxocyclohex-3-ene-1-carboxylate, methyl 2-(2,5-dimethoxybenzoyl)-5-(hydroxymethyl)-3-nitro-6-oxobicyclo[2.2.2]octane-1-carboxylate, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition Isoxazoline Cyclization, substituted 1-(1,3-dihydroisobenzofuran-5-yl)-trifluoro-3-phenylbut-2-en-1-one, hydroxylamine hydrochloride, isoxazoline, (1S,2S,4S,5R)-1-(3,5-di-tert-butylbenzyl)-2-((R)-(6-((2,6-dichlorobenzyl)oxy)quinolin-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide, Cupreine DerivativeCyclization, Isoxazoline cyclization Cycloaddition, 2-substituted 2-isocyanopropanoates, nitroalkenes, dihydropyrroles, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine Derivative[3+2]-Cycloaddition, Cycloaddition Aza-Henry (Nitro-Mannich), substituted 3-iminoindolin-2-one, nitroalkanes, substituted 3-amino-3-(nitromethyl)indolin-2-one, (8α,9R)-9-(Phenylmethoxy)cinchonan-6′-ol, Cupreine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Mannich reaction, N-protected phenylmethanimine, 3-methylindolin-2-one, N-protected (R)-3-((R)-amino(phenyl)methyl)-3-methylindolin-2-one, (8α,9R)-9-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich Spirocyclization, oxindoles, 2-(prop-2-yn-1-yl)malononitrile, spiro[pyrrolidin-3,2′-oxindole] derivatives, 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl gold(I) bis(trifluoromethansulfonyl)imid, (8α,9R)-9-(9-anthracenylmethoxy)-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich, Spirocyclization Atropisomer Synthesis, 1-(phenylethynyl)naphthalen-2-ol, Se-phenyl 4-methylbenzenesulfonoselenoate, atropisomers, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-hydroxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Cupreine DerivativeAtropisomer synthesis Atropisomer Synthesis, diarylalkynes, arylsulfinic acid, N-iodosuccinimide, multiaxis atropisomers, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-hydroxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Cupreine DerivativeAtropisomer synthesis« Older EntriesNext Entries »
Amination, substituted diisopropyl acetylphosphonate, amides, arylmethanamines, sulfurous dichloride, triisopropyl phosphite, substituted diisopropyl (aminomethyl)phosphonate, (8α,9R)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,3′′-terphenyl]-5′-yl]methyl]-6′-hydroxy-cinchonanium bromide, Cupreine DerivativeAmination, Isomerization
Oxa-Michael Addition, ethyl 2-(3,5-dimethylphenyl)-3-nitroacrylate, oximes, ethyl 2-(3,5-dimethylphenyl)-2-(((4-methoxybenzylidene)amino)oxy)-3-nitropropanoate, (9S)-9-[[4-(1,1-dimethylethyl)phenyl]methoxy]-cinchonan-6′-ol, Cupreidine DerivativeMichael Addition, Oxa-Michael Addition
Michael Addition, 1-(2,5-dimethoxyphenyl)-3-nitroprop-2-en-1-one, methyl 3-(hydroxymethyl)-2-oxocyclohex-3-ene-1-carboxylate, methyl 2-(2,5-dimethoxybenzoyl)-5-(hydroxymethyl)-3-nitro-6-oxobicyclo[2.2.2]octane-1-carboxylate, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Michael, Michael Addition
Isoxazoline Cyclization, substituted 1-(1,3-dihydroisobenzofuran-5-yl)-trifluoro-3-phenylbut-2-en-1-one, hydroxylamine hydrochloride, isoxazoline, (1S,2S,4S,5R)-1-(3,5-di-tert-butylbenzyl)-2-((R)-(6-((2,6-dichlorobenzyl)oxy)quinolin-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide, Cupreine DerivativeCyclization, Isoxazoline cyclization
Cycloaddition, 2-substituted 2-isocyanopropanoates, nitroalkenes, dihydropyrroles, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine Derivative[3+2]-Cycloaddition, Cycloaddition
Aza-Henry (Nitro-Mannich), substituted 3-iminoindolin-2-one, nitroalkanes, substituted 3-amino-3-(nitromethyl)indolin-2-one, (8α,9R)-9-(Phenylmethoxy)cinchonan-6′-ol, Cupreine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Mannich reaction, N-protected phenylmethanimine, 3-methylindolin-2-one, N-protected (R)-3-((R)-amino(phenyl)methyl)-3-methylindolin-2-one, (8α,9R)-9-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich
Spirocyclization, oxindoles, 2-(prop-2-yn-1-yl)malononitrile, spiro[pyrrolidin-3,2′-oxindole] derivatives, 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl gold(I) bis(trifluoromethansulfonyl)imid, (8α,9R)-9-(9-anthracenylmethoxy)-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich, Spirocyclization
Atropisomer Synthesis, 1-(phenylethynyl)naphthalen-2-ol, Se-phenyl 4-methylbenzenesulfonoselenoate, atropisomers, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-hydroxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Cupreine DerivativeAtropisomer synthesis
Atropisomer Synthesis, diarylalkynes, arylsulfinic acid, N-iodosuccinimide, multiaxis atropisomers, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-hydroxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Cupreine DerivativeAtropisomer synthesis
