Catalytic Atroposelective aza-Grob Fragmentation: An Approach toward Axially Chiral Biarylnitriles.

DOI Number:

10.1021/jacs.5c02978
Link to literature

Reaction Category:

Atropisomer synthesis

Educt:

(E)-10-((([1,1'-biphenyl]-2-carbonyl)oxy)imino)-4,5-dimethylphenanthren-9(10H)-one, aniline

Product:

axially chiral biarylnitriles

Catalyst:

(8α,9R)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide

Cas No:

960161-13-1

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2