Halide Bond Assisted Double Desymmetrization of Meso‐Dicarboxylic Acids with Symmetrical Olefins via Asymmetric Halogenation.

DOI Number:

10.1002/anie.202520866
Link to literature

Reaction Category:

Bromination | Lactonization

MOP ID:

MOP_0000551

Educt:

substituted bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, N-bromosuccinimide

Product:

6-bromo-6,6a-dibutyl-2-oxohexahydro-2H-3,5-methanocyclopenta[b]furan-7-carboxylic acid

Catalyst:

gold-catalyst, 1-(2-bromophenyl)-3-((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea

Cas No:

3114948-20-5

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2