Primary amine-catalyzed enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones to α,β-unsaturated ketones.

DOI Number:

10.3762/bjoc.20.136
Link to literature

Reaction Category:

Michael | Michael Addition

RXNO ID:

RXNO_0000009

Educt:

α,β-unsaturated ketones, pyrazolin-5-ones

Product:

(S)-3-methyl-4-(3-oxo-1-phenylbutyl)-1-phenyl-1H-pyrazol-5-yl acetate

Catalyst:

(±)-mandelic acid, (8α,9S)-Cinchonan-9-amine

Cas No:

850409-61-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2