re‐and si‐Face‐selective nitroaldol reactions catalyzed by a rigid chiral quaternary ammonium salt: a highly stereoselective synthesis of the HIV protease inhibitor amprenavir (Vertex 478).

DOI Number:

10.1002/(SICI)1521-3773(19990712)38:13/143.0.CO;2-4

Reaction Category:

Educt:

(S)-2-(dibenzylamino)-3-phenylpropanal, nitromethane

Product:

(2R,3S)-3-(dibenzylamino)-1-nitro-4-phenylbutan-2-ol

Catalyst:

1-(9-anthracenylmethyl)-9-(phenylmethoxy)-(8α,9R)-cinchonanium fluoride

Cas No:

244760-53-0

Cas No:

485-71-2