re‐and si‐Face‐selective nitroaldol reactions catalyzed by a rigid chiral quaternary ammonium salt: a highly stereoselective synthesis of the HIV protease inhibitor amprenavir (Vertex 478).
DOI Number:
10.1002/(SICI)1521-3773(19990712)38:13/143.0.CO;2-4
Reaction Category:
RXNO ID:
RXNO_0000086
Educt:
(S)-2-(dibenzylamino)-3-phenylpropanal, nitromethane
Product:
(2R,3S)-3-(dibenzylamino)-1-nitro-4-phenylbutan-2-ol
Catalyst:
1-(9-anthracenylmethyl)-9-(phenylmethoxy)-(8α,9R)-cinchonanium fluoride
Cas No:
244760-53-0
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2