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Aza-Henry (Nitro-Mannich), isatin-derived N-Boc ketimines, substituted (nitromethyl)benzene, substituted tert-butyl ((R)-1-benzyl-3-((S)-nitro(phenyl)methyl)-2-oxoindolin-3-yl)carbamate, (8α,9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-[[[[(1S)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine Derivative

Aza-Henry, Henry, Mannich, Nitro-Mannich

Aza-Henry (Nitro-Mannich), trifluoromethyl ketimines, nitromethane, tert-butyl (S)-(1,1,1-trifluoro-3-nitro-2-substituted-propan-2-yl)carbamate, (8α,9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-[[[[(1S)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine Derivative

Aza-Henry, Henry, Mannich, Nitro-Mannich

Alkenylation, tetrahydroisoquinolines, acrylaldehyde, 2-(2-phenyl-tetrahydroisoquinolin-1-yl)acrylaldehyde, Quinine Base

Alkylation, Allylic Alkylation

Aza-Michael Addition, 4-nitrobenzohydrazide, (E)-(2-nitrovinyl)benzene, (R)-4-nitro-N’-(2-nitro-1-phenylethyl)benzohydrazide, 3,4-dimethoxybenzoic acid, Quinine Base

Aza-Michael, Michael Addition

Sulfinylation, sodium benzenesulfinate, isopropanol, isopropyl benzenesulfinate, Quinine Base

Further reactions, Sulfinylation

Amination, 2-substituted indolin-3-ones, (E)-diazene-1,2-dicarboxylates, substituted 1-(1-acetyl-3-oxoindolin-2-yl)hydrazine-1,2-dicarboxylate, Quinine Base

alpha-Amination, Amination

Cyclopropanation, para-quinone methides, substituted 2-bromoacetamide, substituted spiro[2.5]octa-4,7-dien-6-one, Quinine Base

Cyclopropanation

Resolution, biaryls, atropisomers, Quinidine Base

Atropisomer synthesis, Resolution

Resolution, biaryls, atropisomers, Quinine Base

Atropisomer synthesis, Resolution

Phospha Michael Addition, nitroalkenes, diphenyl phosphonate, substituted diphenyl (2-nitroethyl)phosphonate, Quinine Base

Michael Addition, Phospha-Michael Addition

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