Mannich reaction, substituted 2-isocyanoacetate, 4-substituted 2-methyl-1,2,5-thiadiazol-3(2H)-one 1,1-dioxide, substituted (4S)-2-methyl-3-oxo-2,3,3a,4-tetrahydroimidazo[1,5-b][1,2,5]thiadiazole-4-carboxylate 1,1-dioxide, silver acetate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich Michael Addition, nitroalkenes, S,S-diethyl propanebis(thioate), substituted S,S-diethyl 2-(2-nitroethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Michael Addition, α-substituted β-nitroacrylates, 1,3-dicarbonyls, ethyl (R)-3-acetyl-2-(4-methoxyphenyl)-2-(nitromethyl)-4-oxopentanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition Vinylogous Michael Addition, ethyl (Z)-3-nitro-2-phenylacrylate, N-protected (E)-5-chloro-3-(pentan-2-ylidene)indolin-2-one, N-protected ethyl (S,Z)-4-(5-chloro-2-oxoindolin-3-ylidene)-2-(nitromethyl)-2-phenylheptanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael Addition, Vinylogous Michael Addition Domino Michael Addition, cyclic ketones, alkylidene pyrazolones, tetrahydropyrano [2,3-c] pyrazoles, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael, Michael Addition Spirocyclization, oxindoles, 3-chlorooxindoles, Spirooxindoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclopropanation, Spirocyclization Atropisomer Synthesis, naphthamides, substituted 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate, axially chiral naphthamides, Dihydroquinine BaseAlkylation, Allylic Alkylation, Atropisomer synthesis 1,4-Hydrophosphinylation, H-phosphine oxides, substituted 2-(tosylmethyl)aniline, substituted (2-aminobenzyl)phosphine oxide, Dihydroquinine BaseFurther reactions, Hydrophosphinylation, Phosphination Michael Addition, β‐oxo phosphonate, nitro olefins, substituted (R)-(4-nitro-1-oxo-1-phenylbutan-2-yl)phosphonate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael, Michael Addition Sulfa-Michael Addition, α-substituted N-acryloyloxazolidinones, thioacetic acid, S-(3-oxo-3-(2-oxooxazolidin-3-yl)propyl) ethanethioate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition« Older EntriesNext Entries »
Mannich reaction, substituted 2-isocyanoacetate, 4-substituted 2-methyl-1,2,5-thiadiazol-3(2H)-one 1,1-dioxide, substituted (4S)-2-methyl-3-oxo-2,3,3a,4-tetrahydroimidazo[1,5-b][1,2,5]thiadiazole-4-carboxylate 1,1-dioxide, silver acetate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich
Michael Addition, nitroalkenes, S,S-diethyl propanebis(thioate), substituted S,S-diethyl 2-(2-nitroethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Michael Addition, α-substituted β-nitroacrylates, 1,3-dicarbonyls, ethyl (R)-3-acetyl-2-(4-methoxyphenyl)-2-(nitromethyl)-4-oxopentanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition
Vinylogous Michael Addition, ethyl (Z)-3-nitro-2-phenylacrylate, N-protected (E)-5-chloro-3-(pentan-2-ylidene)indolin-2-one, N-protected ethyl (S,Z)-4-(5-chloro-2-oxoindolin-3-ylidene)-2-(nitromethyl)-2-phenylheptanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael Addition, Vinylogous Michael Addition
Domino Michael Addition, cyclic ketones, alkylidene pyrazolones, tetrahydropyrano [2,3-c] pyrazoles, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael, Michael Addition
Spirocyclization, oxindoles, 3-chlorooxindoles, Spirooxindoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclopropanation, Spirocyclization
Atropisomer Synthesis, naphthamides, substituted 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate, axially chiral naphthamides, Dihydroquinine BaseAlkylation, Allylic Alkylation, Atropisomer synthesis
1,4-Hydrophosphinylation, H-phosphine oxides, substituted 2-(tosylmethyl)aniline, substituted (2-aminobenzyl)phosphine oxide, Dihydroquinine BaseFurther reactions, Hydrophosphinylation, Phosphination
Michael Addition, β‐oxo phosphonate, nitro olefins, substituted (R)-(4-nitro-1-oxo-1-phenylbutan-2-yl)phosphonate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael, Michael Addition
Sulfa-Michael Addition, α-substituted N-acryloyloxazolidinones, thioacetic acid, S-(3-oxo-3-(2-oxooxazolidin-3-yl)propyl) ethanethioate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
