Sulfa-Michael Addition, β‐substituted‐β‐trifluoromethyl oxazolidinone enoates, mercaptans, substituted 3-(4,4,4-trifluoro-3-mercaptobutanoyl)oxazolidin-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Spirocyclization, 3-isothiocyanato oxindoles, 3-nitroindoles, polycyclic spirooxindoles, (1β,4β,9R)-9-[N-[3,5-bis(trifluoromethyl)phenyl]carbamothioate]-6′-methoxy-Cinchonan-9-ol, Quinine DerivativeCascade reaction, Spirocyclization Addition, aldehydes, phenylacetylene, (S)-1-aryl-3-phenylprop-2-yn-1-ols, Cinchonidine BaseAddition Cyclopropanation, chloromethyl ketones, β-substituted methylidenemalononitriles, trans-cyclopropanes, Cinchonidine BaseCyclopropanation interrupted Barton-Zard reaction, 1-protected 3-nitro-1H-indole, 2-substituted 2-isocyanoacetates, substituted 8b-nitro-3,3a,4,8b-tetrahydropyrrolo[3,4-b]indole-3-carboxylate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeBarton-Zard reaction, Dearomatization, Further reactions Amination, benzyl 2-benzylhydrazine-1-carboxylate, α, β‐unsaturated ketones, benzyl 2-benzyl-2-(2-oxoheptan-4-yl)hydrazine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination Mannich reaction, 6,8-dibromobenzo[e][1,2,3]oxathiazine 2,2-dioxide, ethyl 3-oxobutanoate, ethyl (S)-4-(6,8-dibromo-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-oxobutanoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMannich, Mannich Strecker reaction, 1-benzyl-7-fluoro-3-iminoindolin-2-one, trimethylsilanecarbonitrile, (S)-3-amino-1-benzyl-7-fluoro-2-oxoindoline-3-carbonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker Hetero Diels-Alder, 1-((2′-bromo-[1,1′-biphenyl]-2-yl)ethynyl)naphthalen-2-ol, N-Bromosuccinimide, (7aR,11aS,16S,16aS)-11,16-dibromo-16,16a-dihydro-7aH-benzo[a]indeno[1,2-l]xanthene, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-4-(trifluoromethyl)benzamide, Quinine DerivativeCycloaddition, Diels-Alder reaction, Spirocyclization Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation« Older EntriesNext Entries »
Sulfa-Michael Addition, β‐substituted‐β‐trifluoromethyl oxazolidinone enoates, mercaptans, substituted 3-(4,4,4-trifluoro-3-mercaptobutanoyl)oxazolidin-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Spirocyclization, 3-isothiocyanato oxindoles, 3-nitroindoles, polycyclic spirooxindoles, (1β,4β,9R)-9-[N-[3,5-bis(trifluoromethyl)phenyl]carbamothioate]-6′-methoxy-Cinchonan-9-ol, Quinine DerivativeCascade reaction, Spirocyclization
Cyclopropanation, chloromethyl ketones, β-substituted methylidenemalononitriles, trans-cyclopropanes, Cinchonidine BaseCyclopropanation
interrupted Barton-Zard reaction, 1-protected 3-nitro-1H-indole, 2-substituted 2-isocyanoacetates, substituted 8b-nitro-3,3a,4,8b-tetrahydropyrrolo[3,4-b]indole-3-carboxylate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeBarton-Zard reaction, Dearomatization, Further reactions
Amination, benzyl 2-benzylhydrazine-1-carboxylate, α, β‐unsaturated ketones, benzyl 2-benzyl-2-(2-oxoheptan-4-yl)hydrazine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination
Mannich reaction, 6,8-dibromobenzo[e][1,2,3]oxathiazine 2,2-dioxide, ethyl 3-oxobutanoate, ethyl (S)-4-(6,8-dibromo-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-oxobutanoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMannich, Mannich
Strecker reaction, 1-benzyl-7-fluoro-3-iminoindolin-2-one, trimethylsilanecarbonitrile, (S)-3-amino-1-benzyl-7-fluoro-2-oxoindoline-3-carbonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker
Hetero Diels-Alder, 1-((2′-bromo-[1,1′-biphenyl]-2-yl)ethynyl)naphthalen-2-ol, N-Bromosuccinimide, (7aR,11aS,16S,16aS)-11,16-dibromo-16,16a-dihydro-7aH-benzo[a]indeno[1,2-l]xanthene, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-4-(trifluoromethyl)benzamide, Quinine DerivativeCycloaddition, Diels-Alder reaction, Spirocyclization
Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation
