Michael Addition, α-monosubstituted β-tetralones, nitroolefins, α-disubstituted β-tetralones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Michael Addition, α‐branched aryl acetaldehydes, nitroolefins, 2,2,3‐trisubstituted syn γ‐nitroaldehydes, (S)-N-((S)-3,3-dimethyl-1-oxo-1-(piperidin-1-yl)butan-2-yl)-2-((2-(((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)-3,3-dimethylbutanamide, Quinine DerivativeMichael, Michael Addition Michael Addition, α-branched α-amino aldehydes, nitroolefins, α-amino aldehydes, (2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[[2-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3,3-dimethyl Butanamide, Quinine DerivativeMichael, Michael Addition Cyclopropanation, substituted 6,7-dihydro-2H-chromen-2-one, tert-butyl 2-bromoacetate, substituted tert-butyl (1S,7bR)-2-oxo-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-1-carboxylate, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclopropanation Michael Addition, ynones, α-amido sulfones, axially chiral styrenes, (2S)-2-[[2-[[3,5-bis(trifluoromethyl)phenyl]amino]-4,5-dioxo-1-cyclobuten-1-yl]amino]-N-[(9S)-6′-methoxycinchonan-9-yl]-3-methyl-butanamide, Quinine DerivativeAtropisomer synthesis, Michael, Michael Addition Spirocyclization, polycyclic naphthols, polycyclic tetralones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Oxa-Michael Addition, Spirocyclization Michael Addition, nitroalkenes, dimethyl malonate, substituted dimethyl 2-(2-nitroethyl)malonate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition Cascade Reaction, substituted ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, thiols, aldehydes, primary amines, thiolated spiro-γ-lactam oxindoles, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]- N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCascade reaction Cascade Reaction, 1,12-diphenyldodeca-2,4,6,8,10-pentaene-1,12-dione, hydrazine hydrate, 1-phenyl-2-((3aR,8R)-2-phenyl-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindol-8-yl)ethan-1-one, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction Cyclopropanation, conjugated cyanosulfones, dimethyl 2-bromomalonate, 3-substituted dimethyl (2S,3R)-2-cyano-2-(phenylsulfonyl)cyclopropane-1,1-dicarboxylate, (8α,9R)-10,11-dihydro-9-(4-pentenoate)cinchonan-6′,9-diol, Dihydrocupreine DerivativeCyclopropanation« Older EntriesNext Entries »
Michael Addition, α-monosubstituted β-tetralones, nitroolefins, α-disubstituted β-tetralones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Michael Addition, α‐branched aryl acetaldehydes, nitroolefins, 2,2,3‐trisubstituted syn γ‐nitroaldehydes, (S)-N-((S)-3,3-dimethyl-1-oxo-1-(piperidin-1-yl)butan-2-yl)-2-((2-(((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)-3,3-dimethylbutanamide, Quinine DerivativeMichael, Michael Addition
Michael Addition, α-branched α-amino aldehydes, nitroolefins, α-amino aldehydes, (2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[[2-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3,3-dimethyl Butanamide, Quinine DerivativeMichael, Michael Addition
Cyclopropanation, substituted 6,7-dihydro-2H-chromen-2-one, tert-butyl 2-bromoacetate, substituted tert-butyl (1S,7bR)-2-oxo-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-1-carboxylate, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclopropanation
Michael Addition, ynones, α-amido sulfones, axially chiral styrenes, (2S)-2-[[2-[[3,5-bis(trifluoromethyl)phenyl]amino]-4,5-dioxo-1-cyclobuten-1-yl]amino]-N-[(9S)-6′-methoxycinchonan-9-yl]-3-methyl-butanamide, Quinine DerivativeAtropisomer synthesis, Michael, Michael Addition
Spirocyclization, polycyclic naphthols, polycyclic tetralones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Oxa-Michael Addition, Spirocyclization
Michael Addition, nitroalkenes, dimethyl malonate, substituted dimethyl 2-(2-nitroethyl)malonate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition
Cascade Reaction, substituted ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, thiols, aldehydes, primary amines, thiolated spiro-γ-lactam oxindoles, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]- N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCascade reaction
Cascade Reaction, 1,12-diphenyldodeca-2,4,6,8,10-pentaene-1,12-dione, hydrazine hydrate, 1-phenyl-2-((3aR,8R)-2-phenyl-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindol-8-yl)ethan-1-one, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction
Cyclopropanation, conjugated cyanosulfones, dimethyl 2-bromomalonate, 3-substituted dimethyl (2S,3R)-2-cyano-2-(phenylsulfonyl)cyclopropane-1,1-dicarboxylate, (8α,9R)-10,11-dihydro-9-(4-pentenoate)cinchonan-6′,9-diol, Dihydrocupreine DerivativeCyclopropanation
