Cascade reaction, diethyl 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate, tert-butyl (Z)-2-(3,5-dimethylphenyl)-3-nitroacrylate, 2-(tert-butyl) 4-ethyl (S)-2-(3,5-dimethylphenyl)-3-nitro-2,5-dihydrothiophene-2,4-dicarboxylate, 3-[(3,5-dimethylphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Michael Addition, 1-Methyl-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 1-(3-Methylphenyl)-2-propen-1-one, (5R)-1-Methyl-5-[3-(3-methylphenyl)-3-oxopropyl]-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 3-[[3-[bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl]-5-(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Heteroannulation, dinaphtho[2,1-b:1′,2′-d]furan-2-ol, (Z)-1-(2-chloro-2-nitrovinyl)-4-(trifluoromethyl)benzene, dioxa[6]helicenes, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Heteroannulation Mannich reaction, 4-methoxy-6-methylpyrimidin-2-amine, malonic acid esters, aldehydes, amino-pyrimidine derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich [4+2]-Cycloaddition, vinylidene ortho-quinone methides, benzofurans, oxygen-containing [5-6-5] tricyclic heterocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[4+2]-Cycloaddition, Cyclization, Cycloaddition Aldol reaction, 2-nitrobenzaldehyde, acetone, 4-hydroxy-4-(2-nitrophenyl)butan-2-one, (2S)-N-(8α,9S)-cinchonan-9-yl-2-Pyrrolidinecarboxamide, Cinchonidine DerivativeAldol, Aldol Pictet-Spengler, methyl 2,2-dimethoxy-5-oxopentanoate, substituted 2-(1H-indol-3-yl)ethan-1-amine, substituted methyl 2,2-dimethoxy-4-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction Mannich reaction, isatin derived N-boc ketimines, 1,3-diketones, 3-amino-oxindoles, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Michael Addition, 1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, 2-chloroacrylonitrile, (S)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, (R)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition Biginelli reaction, aldehydes, thiourea, 4-methyl-3-oxopentanoic acid esters, 6-isopropyl-3,4-dihydropyrimidines, (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions« Older EntriesNext Entries »
Cascade reaction, diethyl 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate, tert-butyl (Z)-2-(3,5-dimethylphenyl)-3-nitroacrylate, 2-(tert-butyl) 4-ethyl (S)-2-(3,5-dimethylphenyl)-3-nitro-2,5-dihydrothiophene-2,4-dicarboxylate, 3-[(3,5-dimethylphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Michael Addition, 1-Methyl-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 1-(3-Methylphenyl)-2-propen-1-one, (5R)-1-Methyl-5-[3-(3-methylphenyl)-3-oxopropyl]-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 3-[[3-[bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl]-5-(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Heteroannulation, dinaphtho[2,1-b:1′,2′-d]furan-2-ol, (Z)-1-(2-chloro-2-nitrovinyl)-4-(trifluoromethyl)benzene, dioxa[6]helicenes, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Heteroannulation
Mannich reaction, 4-methoxy-6-methylpyrimidin-2-amine, malonic acid esters, aldehydes, amino-pyrimidine derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
[4+2]-Cycloaddition, vinylidene ortho-quinone methides, benzofurans, oxygen-containing [5-6-5] tricyclic heterocycles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[4+2]-Cycloaddition, Cyclization, Cycloaddition
Aldol reaction, 2-nitrobenzaldehyde, acetone, 4-hydroxy-4-(2-nitrophenyl)butan-2-one, (2S)-N-(8α,9S)-cinchonan-9-yl-2-Pyrrolidinecarboxamide, Cinchonidine DerivativeAldol, Aldol
Pictet-Spengler, methyl 2,2-dimethoxy-5-oxopentanoate, substituted 2-(1H-indol-3-yl)ethan-1-amine, substituted methyl 2,2-dimethoxy-4-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction
Mannich reaction, isatin derived N-boc ketimines, 1,3-diketones, 3-amino-oxindoles, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Michael Addition, 1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, 2-chloroacrylonitrile, (S)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, (R)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition
Biginelli reaction, aldehydes, thiourea, 4-methyl-3-oxopentanoic acid esters, 6-isopropyl-3,4-dihydropyrimidines, (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions
